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The study of the oipA and dupA genes in Helicobacter pylori strains and their
relationship with different gastroduodenal diseases
#MMPMID26171137
Souod N
; Sarshar M
; Dabiri H
; Momtaz H
; Kargar M
; Mohammadzadeh A
; Abdi S
Gastroenterol Hepatol Bed Bench
2015[Spr]; 8
(Suppl 1
): S47-53
PMID26171137
show ga
AIM: The purpose of this investigation was to determine the oipA and dupA genes
of Helicobacter pylori isolates from west of Iran; Chaharmahalo Bakhtiyari region
and find their relationship with the severity of the gastroduodenal diseases.
BACKGROUND: Helicobacter pylori is an organism responsible for many
gastroduodenal diseases. Many studies suggest that genetic diversity in H .
pylori virulence factors such as oipA and dupA genes is high among isolates of
different geographic regions and may cause more severe diseases. PATIENTS AND
METHODS: In this cross-sectional study, gastric biopsy specimens were taken from
150 patients suffering from gastroduodenal diseases. The presence of ureC, dupA
and oipA genes was tested by polymerase chain reaction (PCR). RESULTS: Overall,
123 (82%) H. pylori strains were isolated from 150 specimens. dupA gene was
detected in 41 (33.33%) H.pylori-positive specimens. There was a reverse
correlation between this gene and gastric cancer. The oipA gene was found in 88
(71.54%) samples and statistically there was no association between this gene and
gastric disorders. As statistical analyses revealed, the presence of the dupA was
more common in isolates with the oipA negative. CONCLUSION: Based on our
findings, the presence of dupA gene can be considered as a marker for the onset
of severe diseases. However, the oipA gene cannot be regarded for prediction of
gastroenterology diseases. Meanwhile, extended molecular epidemiology researches
in other populations are recommended.
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