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Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Gastroenterol+Hepatol+Bed+Bench 2015 ; 8 (Suppl1): S15-22 Nephropedia Template TP
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Genetic and molecular aspects of Helicobacterpylori in gastritis, pre- cancerous conditions and gastric adenocrcinoma #MMPMID26171133
Shadifar M; Ataee R; Ataie A; Heydari Gorgi AM; Nasri Nasrabadi N; Nouri S
Gastroenterol Hepatol Bed Bench 2015[Spr]; 8 (Suppl1): S15-22 PMID26171133show ga
Gastric adenocarcinoma is one of the most common malignancies worldwide. Many ethological causes have been introduced among which helicobacter pylori, as a gram-negative bacterium has been considered as an important pathological facilitating factor. This agent is also associated with different digestive diseases, such as gastritis, peptic ulcer, and mucosa-associated lymphoid tissue lymphoma. Recently, scientists have been described some molecular aspects that show the role of some apoptotic genes and proteins; for example: P53, Bcl2, C-Myc and Rb-suppressor systems in the H. pylori pathogenesis. Also the relationship between nitric oxide (NOSi genotype) with H. pylori infection has been shown. The aim of this mini-review is to explain better these genetically aspects of H.pylori pathogenesis.