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10.7150/ijbs.11729 http://scihub22266oqcxt.onion/10.7150/ijbs.11729 C4495407!4495407 !26157344     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26157344 &cmd=llinks): Failed to open stream: HTTP request failed! 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Mild ischemic injury leads to long-term alterations in the kidney: amelioration by spironolactone administration |pdf=|usr=}}{{26157344 }} gab.com Text Mild ischemic injury leads to long-term alterations in the kidney: amelioration by spironolactone administration JO: Int J Biol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26157344 #FOAvip Administration of the mineralocorticoid receptor antagonist spironolactone prevents the development of chronic kidney disease (CKD) after a severe ischemic injury. However, whether brief periods of ischemia lead to CKD and whether spironolactone administration after ischemia may be a useful therapeutic strategy to prevent the gradual deterioration of structure and function remains unexplored. Nineteen male Wistar rats were divided into four groups: rats that underwent renal bilateral ischemia for 10, 20, or 45 min were compared with sham operated rats. Additionally, thirteen male Wistar rats that underwent renal bilateral ischemia for 20 min were divided into an untreated ischemic group (I) and two groups receiving spironolactone, 20 mg/kg by gavage, at either 0 (Sp0) or 1.5-h after ischemia (Sp1.5). The rats were followed up and studied after 9 months. Mild (20 min) and severe (45 min) ischemia induced a progressive increase in proteinuria at varying magnitudes, whereas minor ischemia (10 min) did not modify proteinuria. CKD induced by moderate ischemia was characterized by renal hypertrophy and tubulointerstitial fibrosis. These effects were associated with activation of the transforming growth factor ? (TGF?) signaling pathway and up-regulation of endothelin receptor A (ETA) and alpha smooth muscle actin (?SMA). Spironolactone treatment immediately or 1.5-h after the ischemic insult prevented the onset of these disorders. Our results show that moderate ischemic insult leads to long-term structural and molecular changes that may compromise renal function in later stages. Additionally, we demonstrate that spironolactone administration after mild ischemia prevents this detrimental effect. Twit Text FOAVip Mild ischemic injury leads to long-term alterations in the kidney: amelioration by spironolactone administration ????Int J Biol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26157344 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26157344 #FOAvip English Wikipedia <ref>{{Cite pmid|26157344 }}</ref> Mild ischemic injury leads to long-term alterations in the kidney: amelioration by spironolactone administration #MMPMID26157344 Barrera-Chimal J ; Pérez-Villalva R ; Ortega JA ; Sánchez A ; Rodríguez-Romo R ; Durand M ; Jaisser F ; Bobadilla NA Int J Biol Sci 2015[]; 11 (8 ): 892-900 PMID26157344 show ga Administration of the mineralocorticoid receptor antagonist spironolactone prevents the development of chronic kidney disease (CKD) after a severe ischemic injury. However, whether brief periods of ischemia lead to CKD and whether spironolactone administration after ischemia may be a useful therapeutic strategy to prevent the gradual deterioration of structure and function remains unexplored. Nineteen male Wistar rats were divided into four groups: rats that underwent renal bilateral ischemia for 10, 20, or 45 min were compared with sham operated rats. Additionally, thirteen male Wistar rats that underwent renal bilateral ischemia for 20 min were divided into an untreated ischemic group (I) and two groups receiving spironolactone, 20 mg/kg by gavage, at either 0 (Sp0) or 1.5-h after ischemia (Sp1.5). The rats were followed up and studied after 9 months. Mild (20 min) and severe (45 min) ischemia induced a progressive increase in proteinuria at varying magnitudes, whereas minor ischemia (10 min) did not modify proteinuria. CKD induced by moderate ischemia was characterized by renal hypertrophy and tubulointerstitial fibrosis. These effects were associated with activation of the transforming growth factor ? (TGF?) signaling pathway and up-regulation of endothelin receptor A (ETA) and alpha smooth muscle actin (?SMA). Spironolactone treatment immediately or 1.5-h after the ischemic insult prevented the onset of these disorders. Our results show that moderate ischemic insult leads to long-term structural and molecular changes that may compromise renal function in later stages. Additionally, we demonstrate that spironolactone administration after mild ischemia prevents this detrimental effect. |Animals [MESH] |Ischemia/*physiopathology [MESH] |Kidney/blood supply/*drug effects/physiopathology [MESH] |Male [MESH] |Proteinuria/physiopathology [MESH] |Rats [MESH] |Rats, Wistar [MESH] |Reperfusion Injury/physiopathology/*prevention & control [MESH]Mild ischemic injury leads to long-term alterations in the kidney: ame(epmc).pdf DeepDyve Pubget Overpricing