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10.1101/gad.264234.115 http://scihub22266oqcxt.onion/10.1101/gad.264234.115 C4495399!4495399 !26109051     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26109051 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Genes+Dev 2015 ; 29 (12 ): 1285-97 Nephropedia Template TP {{tp|p=26109051 |t=2015. Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP |pdf=|usr=}}{{26109051 }} gab.com Text Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP JO: Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=26109051 #FOAvip The Hippo signaling pathway converges on YAP to regulate growth, differentiation, and regeneration. Previous studies with overexpressed proteins have shown that YAP is phosphorylated by its upstream kinase, Lats1/2, on multiple sites, including an evolutionarily conserved 14-3-3-binding site whose phosphorylation is believed to inhibit YAP by excluding it from the nucleus. Indeed, nuclear localization of YAP or decreased YAP phosphorylation at this site (S168 in Drosophila, S127 in humans, and S112 in mice) is widely used in current literature as a surrogate of YAP activation even though the physiological importance of this phosphorylation event in regulating endogenous YAP activity has not been defined. Here we address this question by introducing a Yap(S112A) knock-in mutation in the endogenous Yap locus. The Yap(S112A) mice are surprisingly normal despite nuclear localization of the mutant YAP protein in vivo and profound defects in cytoplasmic translocation in vitro. Interestingly, the mutant Yap(S112A) mice show a compensatory decrease in YAP protein levels due to increased phosphorylation at a mammalian-specific phosphodegron site on YAP. These findings reveal a robust homeostatic mechanism that maintains physiological levels of YAP activity and caution against the assumptive use of YAP localization alone as a surrogate of YAP activity. Twit Text FOAVip Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP ????Genes Dev http://www.kidney.de/pget.php?&tw=1&pmid=26109051 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26109051 #FOAvip English Wikipedia <ref>{{Cite pmid|26109051 }}</ref> Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP #MMPMID26109051 Chen Q ; Zhang N ; Xie R ; Wang W ; Cai J ; Choi KS ; David KK ; Huang B ; Yabuta N ; Nojima H ; Anders RA ; Pan D Genes Dev 2015[Jun]; 29 (12 ): 1285-97 PMID26109051 show ga The Hippo signaling pathway converges on YAP to regulate growth, differentiation, and regeneration. Previous studies with overexpressed proteins have shown that YAP is phosphorylated by its upstream kinase, Lats1/2, on multiple sites, including an evolutionarily conserved 14-3-3-binding site whose phosphorylation is believed to inhibit YAP by excluding it from the nucleus. Indeed, nuclear localization of YAP or decreased YAP phosphorylation at this site (S168 in Drosophila, S127 in humans, and S112 in mice) is widely used in current literature as a surrogate of YAP activation even though the physiological importance of this phosphorylation event in regulating endogenous YAP activity has not been defined. Here we address this question by introducing a Yap(S112A) knock-in mutation in the endogenous Yap locus. The Yap(S112A) mice are surprisingly normal despite nuclear localization of the mutant YAP protein in vivo and profound defects in cytoplasmic translocation in vitro. Interestingly, the mutant Yap(S112A) mice show a compensatory decrease in YAP protein levels due to increased phosphorylation at a mammalian-specific phosphodegron site on YAP. These findings reveal a robust homeostatic mechanism that maintains physiological levels of YAP activity and caution against the assumptive use of YAP localization alone as a surrogate of YAP activity. |Adaptor Proteins, Signal Transducing/*genetics/*metabolism [MESH] |Animals [MESH] |Cell Cycle Proteins [MESH] |Cell Nucleus/metabolism [MESH] |Cells, Cultured [MESH] |Cytoplasm/metabolism [MESH] |Feedback, Physiological [MESH] |Gene Expression Regulation, Developmental [MESH] |Gene Knock-In Techniques [MESH] |Hippo Signaling Pathway [MESH] |Homeostasis/genetics/*physiology [MESH] |Liver/pathology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mutation [MESH] |Phosphoproteins/*genetics/*metabolism [MESH] |Phosphorylation [MESH] |Protein Binding [MESH] |Protein Serine-Threonine Kinases/*physiology [MESH] |Protein Transport/genetics [MESH] |Signal Transduction/*physiology [MESH]Homeostatic control of Hippo signaling activity revealed by an endogen(epmc).pdf DeepDyve Pubget Overpricing