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10.1101/gad.262816.115

http://scihub22266oqcxt.onion/10.1101/gad.262816.115
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C4495398!4495398!26109050
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suck abstract from ncbi


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pmid26109050      Genes+Dev 2015 ; 29 (12): 1271-84
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  • A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis #MMPMID26109050
  • Moroishi T; Park HW; Qin B; Chen Q; Meng Z; Plouffe SW; Taniguchi K; Yu FX; Karin M; Pan D; Guan KL
  • Genes Dev 2015[Jun]; 29 (12): 1271-84 PMID26109050show ga
  • In this study, Moroishi et al. show that YAP and TAZ activation induces the negative regulators LATS1 kinase and LATS2 kinase to constitute a negative feedback mechanism to control YAP/TAZ activation duration and cellular response. This study provides new insights into the dynamic regulation and maintenance of Hippo pathway homeostasis.
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