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10.1016/j.celrep.2015.02.051 http://scihub22266oqcxt.onion/10.1016/j.celrep.2015.02.051 C4494996!4494996!25801023     free     free     free       Cell+Rep 2015 ; 10 (11): 1836-49 Nephropedia Template TP {{tp|p=25801023|t=2015. Activation of necroptosis in multiple sclerosis |pdf=|usr=}}{{25801023}} gab.com Text Activation of necroptosis in multiple sclerosis JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25801023 #FOAvip Multiple sclerosis (MS), a common neurodegenerative disease of the CNS, is characterized by the loss of oligodendrocytes and demyelination. TNF?, a proinflammatory cytokine implicated in MS, can activate necroptosis, a necrotic cell death pathway regulated by RIPK1 and RIPK3 under caspase-8 deficient conditions. Here, we demonstrate defective caspase-8 activation, as well as, activation of RIPK1, RIPK3 and MLKL, the hallmark mediators of necroptosis, in the cortical lesions of human MS pathological samples. Furthermore, we show that MS pathological samples are characterized by an increased insoluble proteome in common with other neurodegenerative diseases such as AD, PD and HD. Finally, we show that necroptosis mediates oligodendrocyte degeneration induced by TNF?, and inhibition of RIPK1 protects against oligodendrocyte cell death in two animal models of MS and in culture. Our findings demonstrate that necroptosis is involved in MS and suggest that targeting RIPK1 may represent a novel therapeutic strategy for MS. Twit Text FOAVip Activation of necroptosis in multiple sclerosis ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25801023 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25801023 #FOAvip English Wikipedia <ref>{{Cite pmid|25801023}}</ref> Activation of necroptosis in multiple sclerosis #MMPMID25801023 Ofengeim D; Ito Y; Najafov A; Zhang Y; Shan B; DeWitt JP; Ye J; Zhang X; Chang A; Vakifahmetoglu-Norberg H; Geng J; Py B; Zhou W; Amin P; Lima JB; Qi C; Yu Q; Trapp B; Yuan J Cell Rep 2015[Mar]; 10 (11): 1836-49 PMID25801023show ga Multiple sclerosis (MS), a common neurodegenerative disease of the CNS, is characterized by the loss of oligodendrocytes and demyelination. TNF?, a proinflammatory cytokine implicated in MS, can activate necroptosis, a necrotic cell death pathway regulated by RIPK1 and RIPK3 under caspase-8 deficient conditions. Here, we demonstrate defective caspase-8 activation, as well as, activation of RIPK1, RIPK3 and MLKL, the hallmark mediators of necroptosis, in the cortical lesions of human MS pathological samples. Furthermore, we show that MS pathological samples are characterized by an increased insoluble proteome in common with other neurodegenerative diseases such as AD, PD and HD. Finally, we show that necroptosis mediates oligodendrocyte degeneration induced by TNF?, and inhibition of RIPK1 protects against oligodendrocyte cell death in two animal models of MS and in culture. Our findings demonstrate that necroptosis is involved in MS and suggest that targeting RIPK1 may represent a novel therapeutic strategy for MS. äActivation of necroptosis in multiple sclerosis (epmc).pdf DeepDyve Pubget Overpricing