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http://scihub22266oqcxt.onion/ C4494946!4494946!25881543     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2015 ; 6 (14): 12392-404 Nephropedia Template TP {{tp|p=25881543|t=2015. TOPK is highly expressed in circulating tumor cells, enabling metastasis of prostate cancer |pdf=|usr=}}{{25881543}} gab.com Text TOPK is highly expressed in circulating tumor cells, enabling metastasis of prostate cancer JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25881543 #FOAvip Circulating tumor cells (CTCs) are important for metastasis in prostate cancer. T-LAK cell-originated protein kinase (TOPK) is highly expressed in cancer cells. Herein, we established a xenograft animal model, isolated and cultured the CTCs, and found CTCs have significantly greater migratory capacity than parental cells. TOPK is more highly expressed in the CTCs than in parental cells and is also highly expressed in the metastatic nodules caused by CTCs in mice. Knocking down TOPK decreased the migration of CTCs both in vitro and in vivo. TOPK was modulated by the PI3K/PTEN and ERK pathways during the metastasis of prostate cancer. High levels of TOPK in the tumors of patients were correlated with advanced stages of prostate cancer, especially for high-risk patients of Gleason score?8, PSA>20ng/ml. In summary, TOPK was speculated to be one of a potential marker and therapeutic target in advanced prostate cancer. Twit Text FOAVip TOPK is highly expressed in circulating tumor cells, enabling metastasis of prostate cancer ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25881543 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25881543 #FOAvip English Wikipedia <ref>{{Cite pmid|25881543}}</ref> TOPK is highly expressed in circulating tumor cells, enabling metastasis of prostate cancer #MMPMID25881543 Sun H; Zhang L; Shi C; Hu P; Yan W; Wang Z; Duan Q; Lu F; Qin L; Lu T; Xiao J; Wang Y; Zhu F; Shao C Oncotarget 2015[May]; 6 (14): 12392-404 PMID25881543show ga Circulating tumor cells (CTCs) are important for metastasis in prostate cancer. T-LAK cell-originated protein kinase (TOPK) is highly expressed in cancer cells. Herein, we established a xenograft animal model, isolated and cultured the CTCs, and found CTCs have significantly greater migratory capacity than parental cells. TOPK is more highly expressed in the CTCs than in parental cells and is also highly expressed in the metastatic nodules caused by CTCs in mice. Knocking down TOPK decreased the migration of CTCs both in vitro and in vivo. TOPK was modulated by the PI3K/PTEN and ERK pathways during the metastasis of prostate cancer. High levels of TOPK in the tumors of patients were correlated with advanced stages of prostate cancer, especially for high-risk patients of Gleason score?8, PSA>20ng/ml. In summary, TOPK was speculated to be one of a potential marker and therapeutic target in advanced prostate cancer. äTOPK is highly expressed in circulating tumor cells, enabling metastas(epmc).pdf DeepDyve Pubget Overpricing