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http://scihub22266oqcxt.onion/ C4494934!4494934!25909171     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2015 ; 6 (14): 12224-33 Nephropedia Template TP {{tp|p=25909171|t=2015. Identification of a novel TGF-?-miR-122-fibronectin 1/serum response factor signaling cascade and its implication in hepatic fibrogenesis |pdf=|usr=}}{{25909171}} gab.com Text Identification of a novel TGF- -miR-122-fibronectin 1/serum response factor signaling cascade and its implication in hepatic fibrogenesis JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25909171 #FOAvip Transforming growth factor-? (TGF-?) is a potent cytokine that promotes the development of fibrogenic cells, stimulates the expression of fibrosis-related genes, and consequently results in hepatic fibrogenesis. The involvement of miRNAs in this process remains largely unknown. We showed that miR-122 was substantially expressed in hepatic stellate cells (HSCs) and fibroblasts, the major sources of fibrogenic cells in liver tissues. Notably, exposure to TGF-? led to significant downregulation of miR-122. Furthermore, reintroduction of miR-122 suppressed TGF-?-induced expression of fibrosis-related genes, including alpha smooth muscle actin (?-SMA), fibronectin 1 (FN1) and ?1 type I collagen (COL1A1), in HSCs and fibroblasts. Subsequent mechanism investigations revealed that miR-122 directly inhibited FN1 expression by binding to its 3?-untranslated region and indirectly reduced the transcription of ?-SMA and COL1A1 by inhibiting the expression of serum response factor (SRF), a key transcription factor that mediated the activation of fibrogenic cells. Further in vivo studies disclosed that intravenous injection of miR-122-expressing lentivirus successfully increased miR-122 level and reduced the amount of collagen fibrils, FN1 and SRF in the livers of CCl4-treated mice. These findings disclose a novel TGF-?-miR-122-FN1/SRF signaling cascade and its implication in hepatic fibrogenesis, and suggest miR-122 as a promising molecular target for anti-fibrosis therapy. Twit Text FOAVip Identification of a novel TGF- -miR-122-fibronectin 1/serum response factor signaling cascade and its implication in hepatic fibrogenesis ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25909171 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25909171 #FOAvip English Wikipedia <ref>{{Cite pmid|25909171}}</ref> Identification of a novel TGF-?-miR-122-fibronectin 1/serum response factor signaling cascade and its implication in hepatic fibrogenesis #MMPMID25909171 Zeng C; Wang YL; Xie C; Sang Y; Li TJ; Zhang M; Wang R; Zhang Q; Zheng L; Zhuang SM Oncotarget 2015[May]; 6 (14): 12224-33 PMID25909171show ga Transforming growth factor-? (TGF-?) is a potent cytokine that promotes the development of fibrogenic cells, stimulates the expression of fibrosis-related genes, and consequently results in hepatic fibrogenesis. The involvement of miRNAs in this process remains largely unknown. We showed that miR-122 was substantially expressed in hepatic stellate cells (HSCs) and fibroblasts, the major sources of fibrogenic cells in liver tissues. Notably, exposure to TGF-? led to significant downregulation of miR-122. Furthermore, reintroduction of miR-122 suppressed TGF-?-induced expression of fibrosis-related genes, including alpha smooth muscle actin (?-SMA), fibronectin 1 (FN1) and ?1 type I collagen (COL1A1), in HSCs and fibroblasts. Subsequent mechanism investigations revealed that miR-122 directly inhibited FN1 expression by binding to its 3?-untranslated region and indirectly reduced the transcription of ?-SMA and COL1A1 by inhibiting the expression of serum response factor (SRF), a key transcription factor that mediated the activation of fibrogenic cells. Further in vivo studies disclosed that intravenous injection of miR-122-expressing lentivirus successfully increased miR-122 level and reduced the amount of collagen fibrils, FN1 and SRF in the livers of CCl4-treated mice. These findings disclose a novel TGF-?-miR-122-FN1/SRF signaling cascade and its implication in hepatic fibrogenesis, and suggest miR-122 as a promising molecular target for anti-fibrosis therapy. äIdentification of a novel TGF-?-miR-122-fibronectin 1/serum response f(epmc).pdf DeepDyve Pubget Overpricing