Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.18632/oncotarget.3652 http://scihub22266oqcxt.onion/10.18632/oncotarget.3652 C4494934!4494934 !25909171     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25909171 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2015 ; 6 (14 ): 12224-33 Nephropedia Template TP {{tp|p=25909171 |t=2015. Identification of a novel TGF-?-miR-122-fibronectin 1/serum response factor signaling cascade and its implication in hepatic fibrogenesis |pdf=|usr=}}{{25909171 }} gab.com Text Identification of a novel TGF- -miR-122-fibronectin 1/serum response factor signaling cascade and its implication in hepatic fibrogenesis JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25909171 #FOAvip Transforming growth factor-? (TGF-?) is a potent cytokine that promotes the development of fibrogenic cells, stimulates the expression of fibrosis-related genes, and consequently results in hepatic fibrogenesis. The involvement of miRNAs in this process remains largely unknown. We showed that miR-122 was substantially expressed in hepatic stellate cells (HSCs) and fibroblasts, the major sources of fibrogenic cells in liver tissues. Notably, exposure to TGF-? led to significant downregulation of miR-122. Furthermore, reintroduction of miR-122 suppressed TGF-?-induced expression of fibrosis-related genes, including alpha smooth muscle actin (?-SMA), fibronectin 1 (FN1) and ?1 type I collagen (COL1A1), in HSCs and fibroblasts. Subsequent mechanism investigations revealed that miR-122 directly inhibited FN1 expression by binding to its 3'-untranslated region and indirectly reduced the transcription of ?-SMA and COL1A1 by inhibiting the expression of serum response factor (SRF), a key transcription factor that mediated the activation of fibrogenic cells. Further in vivo studies disclosed that intravenous injection of miR-122-expressing lentivirus successfully increased miR-122 level and reduced the amount of collagen fibrils, FN1 and SRF in the livers of CCl4-treated mice. These findings disclose a novel TGF-?-miR-122-FN1/SRF signaling cascade and its implication in hepatic fibrogenesis, and suggest miR-122 as a promising molecular target for anti-fibrosis therapy. Twit Text FOAVip Identification of a novel TGF- -miR-122-fibronectin 1/serum response factor signaling cascade and its implication in hepatic fibrogenesis ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=25909171 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25909171 #FOAvip English Wikipedia <ref>{{Cite pmid|25909171 }}</ref> Identification of a novel TGF-?-miR-122-fibronectin 1/serum response factor signaling cascade and its implication in hepatic fibrogenesis #MMPMID25909171 Zeng C ; Wang YL ; Xie C ; Sang Y ; Li TJ ; Zhang M ; Wang R ; Zhang Q ; Zheng L ; Zhuang SM Oncotarget 2015[May]; 6 (14 ): 12224-33 PMID25909171 show ga Transforming growth factor-? (TGF-?) is a potent cytokine that promotes the development of fibrogenic cells, stimulates the expression of fibrosis-related genes, and consequently results in hepatic fibrogenesis. The involvement of miRNAs in this process remains largely unknown. We showed that miR-122 was substantially expressed in hepatic stellate cells (HSCs) and fibroblasts, the major sources of fibrogenic cells in liver tissues. Notably, exposure to TGF-? led to significant downregulation of miR-122. Furthermore, reintroduction of miR-122 suppressed TGF-?-induced expression of fibrosis-related genes, including alpha smooth muscle actin (?-SMA), fibronectin 1 (FN1) and ?1 type I collagen (COL1A1), in HSCs and fibroblasts. Subsequent mechanism investigations revealed that miR-122 directly inhibited FN1 expression by binding to its 3'-untranslated region and indirectly reduced the transcription of ?-SMA and COL1A1 by inhibiting the expression of serum response factor (SRF), a key transcription factor that mediated the activation of fibrogenic cells. Further in vivo studies disclosed that intravenous injection of miR-122-expressing lentivirus successfully increased miR-122 level and reduced the amount of collagen fibrils, FN1 and SRF in the livers of CCl4-treated mice. These findings disclose a novel TGF-?-miR-122-FN1/SRF signaling cascade and its implication in hepatic fibrogenesis, and suggest miR-122 as a promising molecular target for anti-fibrosis therapy. |Animals [MESH] |Cell Line, Tumor [MESH] |Fibronectins/*metabolism [MESH] |Genetic Diseases, Inborn/*genetics/pathology [MESH] |Humans [MESH] |Liver Cirrhosis/*genetics/pathology [MESH] |Mice [MESH] |MicroRNAs/genetics [MESH] |Signal Transduction [MESH] |Transfection [MESH]Identification of a novel TGF-?-miR-122-fibronectin 1/serum response f(epmc).pdf DeepDyve Pubget Overpricing