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C4494900!4494900!25961153
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suck abstract from ncbi

pmid25961153      Oncotarget 2015 ; 6 (14): 11725-34
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  • The emerging role of CaMKII in cancer #MMPMID25961153
  • Wang Yy; Zhao R; Zhe H
  • Oncotarget 2015[May]; 6 (14): 11725-34 PMID25961153show ga
  • Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional serine/threonine kinases best known for its critical role in learning and memory. Recent studies suggested that high levels of CaMKII also expressed in variety of malignant diseases. In this review, we focus on the structure and biology properties of CaMKII, including the role of CaMKII in the regulation of cancer progression and therapy response. We also describe the role of CaMKII in the diagnosis of different kinds of cancer and recent progress in the development of CaMKII inhibitors. These data establishes CaMKII as a novel target whose modulation presents new opportunities for cancer diagnosis and treatment.
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