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10.1074/mcp.R400009-MCP200 http://scihub22266oqcxt.onion/10.1074/mcp.R400009-MCP200 C4494826!4494826 !15215308     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=15215308 &cmd=llinks): Failed to open stream: HTTP request failed! 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Interaction networks of the molecular machines that decode, replicate, and maintain the integrity of the human genome |pdf=|usr=}}{{15215308 }} gab.com Text Interaction networks of the molecular machines that decode, replicate, and maintain the integrity of the human genome JO: Mol Cell Proteomics http://www.kidney.de/pget.php?&tw=1&pmid=15215308 #FOAvip The interaction of many proteins with genomic DNA is required for the expression, replication, and maintenance of the integrity of mammalian genomes. These proteins participate in processes as diverse as gene transcription and mRNA processing, as well as in DNA replication, recombination, and repair. This intricate system, where the various nuclear machineries interact with one another and bind to either common or distinct DNA regions to create an impressive network of protein-protein and protein-DNA interactions, is made even more complex by the need for a very stringent control in order to ensure normal cell growth and differentiation. A general methodology based on the in vivo pull-down of tagged components of nuclear machines and regulatory proteins was used to study genome-wide protein-protein and protein-DNA interactions in mammalian cells. In particular, this approach has been used in defining the interaction networks (or "interactome") formed by RNA polymerase II, a molecular machine that decodes the human genome. In addition, because this methodology allows for the purification of variant forms of tagged complexes having site-directed mutations in key elements, it can also be used for deciphering the relationship between the structure and the function of the molecular machines, such as RNA polymerase II, that by binding DNA play a central role in the pathway from the genome to the organism. Twit Text FOAVip Interaction networks of the molecular machines that decode, replicate, and maintain the integrity of the human genome ????Mol Cell Proteomics http://www.kidney.de/pget.php?&tw=1&pmid=15215308 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=15215308 #FOAvip English Wikipedia <ref>{{Cite pmid|15215308 }}</ref> Interaction networks of the molecular machines that decode, replicate, and maintain the integrity of the human genome #MMPMID15215308 Coulombe B ; Jeronimo C ; Langelier MF ; Cojocaru M ; Bergeron D Mol Cell Proteomics 2004[Sep]; 3 (9 ): 851-6 PMID15215308 show ga The interaction of many proteins with genomic DNA is required for the expression, replication, and maintenance of the integrity of mammalian genomes. These proteins participate in processes as diverse as gene transcription and mRNA processing, as well as in DNA replication, recombination, and repair. This intricate system, where the various nuclear machineries interact with one another and bind to either common or distinct DNA regions to create an impressive network of protein-protein and protein-DNA interactions, is made even more complex by the need for a very stringent control in order to ensure normal cell growth and differentiation. A general methodology based on the in vivo pull-down of tagged components of nuclear machines and regulatory proteins was used to study genome-wide protein-protein and protein-DNA interactions in mammalian cells. In particular, this approach has been used in defining the interaction networks (or "interactome") formed by RNA polymerase II, a molecular machine that decodes the human genome. In addition, because this methodology allows for the purification of variant forms of tagged complexes having site-directed mutations in key elements, it can also be used for deciphering the relationship between the structure and the function of the molecular machines, such as RNA polymerase II, that by binding DNA play a central role in the pathway from the genome to the organism. |*Genome, Human [MESH] |*Proteome [MESH] |DNA/chemistry/genetics/metabolism [MESH] |Humans [MESH] |Macromolecular Substances [MESH] |Models, Biological [MESH] |Models, Molecular [MESH] |Proteomics/methods [MESH]Interaction networks of the molecular machines that decode, replicate,(epmc).pdf DeepDyve Pubget Overpricing