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10.3892/ijmm.2015.2190 http://scihub22266oqcxt.onion/10.3892/ijmm.2015.2190 C4494601!4494601 !25901787     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25901787 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Med 2015 ; 36 (1 ): 123-9 Nephropedia Template TP {{tp|p=25901787 |t=2015. CCN5 attenuates profibrotic phenotypes of fibroblasts through the Smad6-CCN2 pathway: Potential role in epidural ?brosis |pdf=|usr=}}{{25901787 }} gab.com Text CCN5 attenuates profibrotic phenotypes of fibroblasts through the Smad6-CCN2 pathway: Potential role in epidural brosis JO: Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=25901787 #FOAvip Epidural ?brosis is characterized by the development of dense and thick scar tissue adjacent to the dural mater and ranked as the major contributor for post-operative pain recurrence after laminectomy or discectomy. Recently, CCN5 exhibited an inhibitory effect on connective tissue growth factor (CTGF)/CCN2 (a critical regulator for fibrotic disease)?mediated fibrogenesis. However, its function in epidural fibrosis and the underlying mechanisms involved remain to be determined. In this study, an obvious downregulation of CCN5 was observed in scar tissues from laminectomized rats, concomitant with a marked upregulation of CCN2, suggesting a potential negative regulatory role of CCN5 in fibrogenesis. Furthermore, CCN5 overexpression notably mitigated transforming growth factor??1-enhanced fibroblast viability and proliferation. Of note, CCN5 upregulation inhibited the switch of fibroblasts into myofibroblasts as its overexpression abrogated the expression of the myo?broblast marker, ?-smooth muscle actin (?-SMA). CCN5 upregulation also reduced an increase in collagen type I, ?1 (COL1A1) and total collagen concentrations. Additionally, CCN5 over-expression decreased CCN2 expression and increased Smad6 phosphorylation. Mechanism analysis revealed that blocking Smad6 signaling significantly ameliorated the inhibitory effect of CCN5 on the CCN2 levels, accompanied by the reduction in cell proliferation and collagen production. These results confirm that CCN5 exerts an anti-fibrotic function by regulating the Smad6-CCN2 pathway, thereby indicating a potential approach for ameliorating epidural ?brosis after laminectomy. Twit Text FOAVip CCN5 attenuates profibrotic phenotypes of fibroblasts through the Smad6-CCN2 pathway: Potential role in epidural brosis ????Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=25901787 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25901787 #FOAvip English Wikipedia <ref>{{Cite pmid|25901787 }}</ref> CCN5 attenuates profibrotic phenotypes of fibroblasts through the Smad6-CCN2 pathway: Potential role in epidural ?brosis #MMPMID25901787 Xu H ; Liu C ; Sun Z ; Guo X ; Zhang Y ; Liu M ; Li P Int J Mol Med 2015[Jul]; 36 (1 ): 123-9 PMID25901787 show ga Epidural ?brosis is characterized by the development of dense and thick scar tissue adjacent to the dural mater and ranked as the major contributor for post-operative pain recurrence after laminectomy or discectomy. Recently, CCN5 exhibited an inhibitory effect on connective tissue growth factor (CTGF)/CCN2 (a critical regulator for fibrotic disease)?mediated fibrogenesis. However, its function in epidural fibrosis and the underlying mechanisms involved remain to be determined. In this study, an obvious downregulation of CCN5 was observed in scar tissues from laminectomized rats, concomitant with a marked upregulation of CCN2, suggesting a potential negative regulatory role of CCN5 in fibrogenesis. Furthermore, CCN5 overexpression notably mitigated transforming growth factor??1-enhanced fibroblast viability and proliferation. Of note, CCN5 upregulation inhibited the switch of fibroblasts into myofibroblasts as its overexpression abrogated the expression of the myo?broblast marker, ?-smooth muscle actin (?-SMA). CCN5 upregulation also reduced an increase in collagen type I, ?1 (COL1A1) and total collagen concentrations. Additionally, CCN5 over-expression decreased CCN2 expression and increased Smad6 phosphorylation. Mechanism analysis revealed that blocking Smad6 signaling significantly ameliorated the inhibitory effect of CCN5 on the CCN2 levels, accompanied by the reduction in cell proliferation and collagen production. These results confirm that CCN5 exerts an anti-fibrotic function by regulating the Smad6-CCN2 pathway, thereby indicating a potential approach for ameliorating epidural ?brosis after laminectomy. |Actins/biosynthesis [MESH] |Animals [MESH] |CCN Intercellular Signaling Proteins/biosynthesis/*metabolism [MESH] |Cell Proliferation [MESH] |Cells, Cultured [MESH] |Collagen Type I, alpha 1 Chain [MESH] |Collagen Type I/biosynthesis [MESH] |Connective Tissue Growth Factor/biosynthesis/*metabolism [MESH] |Fibroblasts/physiology [MESH] |Fibrosis/*pathology [MESH] |Laminectomy/adverse effects [MESH] |Male [MESH] |Phosphorylation [MESH] |RNA Interference [MESH] |RNA, Small Interfering [MESH] |Rats [MESH] |Rats, Inbred Lew [MESH] |Repressor Proteins/biosynthesis/*metabolism [MESH] |Signal Transduction [MESH] |Smad6 Protein/genetics/*metabolism [MESH] |Spine/*pathology [MESH]CCN5 attenuates profibrotic phenotypes of fibroblasts through the Smad(epmc).pdf DeepDyve Pubget Overpricing