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Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Am+J+Transl+Res 2015 ; 7 (5): 932-40 Nephropedia Template TP
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Cordyceps sinensis attenuates renal fibrosis and suppresses BAG3 induction in obstructed rat kidney #MMPMID26175854
Du F; Li S; Wang T; Zhang HY; Zong ZH; Du ZX; Li DT; Wang HQ; Liu B; Miao JN; Bian XH
Am J Transl Res 2015[]; 7 (5): 932-40 PMID26175854show ga
BAG3 regulates a number of cellular processes, including cell proliferation, apoptosis, adhesion and migration, and epithelial-mesenchymal transition (EMT). However, the role of BAG3 in renal tubular EMT and renal interstitial fibrosis remains elusive. This study aimed to examine the dynamic expression of BAG3 during renal fibrosis, and to investigate the efficacy of Cordyceps sinensis (C. sinensis) on renal fibrosis. A rat model of unilateral ureteral obstruction (UUO) was established, and the expression of BAG3 and ?-SMA, and the efficacy of C. sinensis on renal fibrosis induced by UUO were examined. The results showed that UUO led to collagen accumulation, which was significantly suppressed by C. sinensis. UUO increased the expression of BAG3 and ?-SMA, a mesenchymal marker, while UUO induced BAG3 and ?-SMA expression was significantly inhibited by C. sinensis. In addition, immunohistochemical staining demonstrated that BAG3 immunoreactivity was restricted to tubular epithelium. In conclusion, BAG3 is a potential target for the prevention and/or treatment of renal fibrosis, and C. Sinensis is a promising agent for renal fibrosis.