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10.1038/srep11888 http://scihub22266oqcxt.onion/10.1038/srep11888 C4493694!4493694 !26149790     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26149790 &cmd=llinks): Failed to open stream: HTTP request failed! 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Intermediate monocytes in ANCA vasculitis: increased surface expression of ANCA autoantigens and IL-1? secretion in response to anti-MPO antibodies |pdf=|usr=}}{{26149790 }} gab.com Text Intermediate monocytes in ANCA vasculitis: increased surface expression of ANCA autoantigens and IL-1 secretion in response to anti-MPO antibodies JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26149790 #FOAvip ANCA vasculitis encompasses several autoimmune conditions characterised by destruction of small vessels, inflammation of the respiratory tract and glomerulonephritis. Most patients harbour autoantibodies to myeloperoxidase (MPO) or proteinase 3 (PR3). Clinical and experimental data suggest that pathogenesis is driven by ANCA-mediated activation of neutrophils and monocytes. We investigated a potential role for distinct monocyte subsets. We found that the relative proportion of intermediate monocytes is increased in patients versus control individuals, and both MPO and PR3 are preferentially expressed on these cells. We demonstrate that MPO and PR3 are expressed independently of each other on monocytes and that PR3 is not associated with CD177. MPO expression correlates with that of Fc receptor CD16 on intermediate monocytes. Monocyte subsets respond differently to antibodies directed against MPO and PR3, with anti-MPO but not anti-PR3 leading to increased IL-1?, IL-6 and IL-8 production. In concordance with the observed higher surface expression of MPO on intermediate monocytes, this subset produces the highest quantity of IL-1? in response to anti-MPO stimulation. These data suggest that monocytes, specifically, the intermediate subset, may play a role in ANCA vasculitis, and also indicate that substantial differences exist between the effect of anti-MPO and anti-PR3 antibodies on these cells. Twit Text FOAVip Intermediate monocytes in ANCA vasculitis: increased surface expression of ANCA autoantigens and IL-1 secretion in response to anti-MPO antibodies ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26149790 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26149790 #FOAvip English Wikipedia <ref>{{Cite pmid|26149790 }}</ref> Intermediate monocytes in ANCA vasculitis: increased surface expression of ANCA autoantigens and IL-1? secretion in response to anti-MPO antibodies #MMPMID26149790 O'Brien EC ; Abdulahad WH ; Rutgers A ; Huitema MG ; O'Reilly VP ; Coughlan AM ; Harrington M ; Heeringa P ; Little MA ; Hickey FB Sci Rep 2015[Jul]; 5 (ä): 11888 PMID26149790 show ga ANCA vasculitis encompasses several autoimmune conditions characterised by destruction of small vessels, inflammation of the respiratory tract and glomerulonephritis. Most patients harbour autoantibodies to myeloperoxidase (MPO) or proteinase 3 (PR3). Clinical and experimental data suggest that pathogenesis is driven by ANCA-mediated activation of neutrophils and monocytes. We investigated a potential role for distinct monocyte subsets. We found that the relative proportion of intermediate monocytes is increased in patients versus control individuals, and both MPO and PR3 are preferentially expressed on these cells. We demonstrate that MPO and PR3 are expressed independently of each other on monocytes and that PR3 is not associated with CD177. MPO expression correlates with that of Fc receptor CD16 on intermediate monocytes. Monocyte subsets respond differently to antibodies directed against MPO and PR3, with anti-MPO but not anti-PR3 leading to increased IL-1?, IL-6 and IL-8 production. In concordance with the observed higher surface expression of MPO on intermediate monocytes, this subset produces the highest quantity of IL-1? in response to anti-MPO stimulation. These data suggest that monocytes, specifically, the intermediate subset, may play a role in ANCA vasculitis, and also indicate that substantial differences exist between the effect of anti-MPO and anti-PR3 antibodies on these cells. |Adolescent [MESH] |Adult [MESH] |Aged [MESH] |Antibodies, Antineutrophil Cytoplasmic/*immunology [MESH] |Antibodies, Monoclonal/immunology [MESH] |Autoantigens/immunology/*metabolism [MESH] |Disease Progression [MESH] |Female [MESH] |Flow Cytometry [MESH] |GPI-Linked Proteins/metabolism [MESH] |Glomerulonephritis/metabolism/pathology [MESH] |Humans [MESH] |Interleukin-1beta/metabolism [MESH] |Interleukin-6/metabolism [MESH] |Interleukin-8/metabolism [MESH] |Isoantigens/metabolism [MESH] |Male [MESH] |Middle Aged [MESH] |Monocytes/immunology/*metabolism [MESH] |Myeloblastin/immunology [MESH] |Neutrophils/immunology/metabolism [MESH] |Peroxidase/*immunology [MESH] |Receptors, Cell Surface/metabolism [MESH] |Receptors, Fc/chemistry/metabolism [MESH] |Receptors, IgG/chemistry/metabolism [MESH] |Vasculitis/metabolism/*pathology [MESH]Intermediate monocytes in ANCA vasculitis: increased surface expressio(epmc).pdf DeepDyve Pubget Overpricing