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10.1038/srep11822 http://scihub22266oqcxt.onion/10.1038/srep11822 C4493574!4493574!26149595     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=26149595|t=2015. Rhein prevents endotoxin-induced acute kidney injury by inhibiting NF-?B activities |pdf=|usr=}}{{26149595}} gab.com Text Rhein prevents endotoxin-induced acute kidney injury by inhibiting NF- B activities JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26149595 #FOAvip This study aimed to explore the effect and mechanisms of rhein on sepsis-induced acute kidney injury by injecting lipopolysaccharide (LPS) and cecal ligation and puncture (CLP) in vivo, and on LPS-induced HK-2 cells in vitro. For histopathological analysis, rhein effectively attenuated the severity of renal injury. Rhein could significantly decrease concentration of BUN and SCr and level of TNF-? and IL-1? in two different mouse models of experimental sepsis. Moreover, rhein could markedly attenuate circulating leukocyte infiltration and enhance phagocytic activity of macrophages partly impaired at 12?h after CLP. Rhein could enhance cell viability and suppresse the release of MCP-1 and IL-8 in LPS-stimulated HK-2 cells Furthermore, rhein down regulated the expression of phosphorylated NF-?B p65, I?B? and IKK? stimulated by LPS both in vivo and in vitro. All these results suggest that rhein has protective effects on endotoxin-induced kidney injury. The underlying mechanism of rhein on anti-endotoxin kidney injury may be closely related with its anti-inflammatory and immunomodulatory properties by decreasing NF-?B activation through restraining the expression and phosphorylation of the relevant proteins in NF-?B signal pathway, hindering transcription of NF-?B p65.These evidence suggest that rhein has a potential application to treat endotoxemia-associated acute kidney injury. Twit Text FOAVip Rhein prevents endotoxin-induced acute kidney injury by inhibiting NF- B activities ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26149595 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26149595 #FOAvip English Wikipedia <ref>{{Cite pmid|26149595}}</ref> Rhein prevents endotoxin-induced acute kidney injury by inhibiting NF-?B activities #MMPMID26149595 Yu C; Qi D; Sun JF; Li P; Fan HY Sci Rep 2015[]; 5 (ä): ä PMID26149595show ga This study aimed to explore the effect and mechanisms of rhein on sepsis-induced acute kidney injury by injecting lipopolysaccharide (LPS) and cecal ligation and puncture (CLP) in vivo, and on LPS-induced HK-2 cells in vitro. For histopathological analysis, rhein effectively attenuated the severity of renal injury. Rhein could significantly decrease concentration of BUN and SCr and level of TNF-? and IL-1? in two different mouse models of experimental sepsis. Moreover, rhein could markedly attenuate circulating leukocyte infiltration and enhance phagocytic activity of macrophages partly impaired at 12?h after CLP. Rhein could enhance cell viability and suppresse the release of MCP-1 and IL-8 in LPS-stimulated HK-2 cells Furthermore, rhein down regulated the expression of phosphorylated NF-?B p65, I?B? and IKK? stimulated by LPS both in vivo and in vitro. All these results suggest that rhein has protective effects on endotoxin-induced kidney injury. The underlying mechanism of rhein on anti-endotoxin kidney injury may be closely related with its anti-inflammatory and immunomodulatory properties by decreasing NF-?B activation through restraining the expression and phosphorylation of the relevant proteins in NF-?B signal pathway, hindering transcription of NF-?B p65.These evidence suggest that rhein has a potential application to treat endotoxemia-associated acute kidney injury. äRhein prevents endotoxin-induced acute kidney injury by inhibiting NF-(epmc).pdf DeepDyve Pubget Overpricing