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10.7150/thno.11642

http://scihub22266oqcxt.onion/10.7150/thno.11642
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C4493540!4493540!26155318
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suck abstract from ncbi


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pmid26155318      Theranostics 2015 ; 5 (9): 1030-44
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  • Nanoparticles for Radiation Therapy Enhancement: the Key Parameters #MMPMID26155318
  • Retif P; Pinel S; Toussaint M; Frochot C; Chouikrat R; Bastogne T; Barberi-Heyob M
  • Theranostics 2015[]; 5 (9): 1030-44 PMID26155318show ga
  • This review focuses on the radiosensitization strategies that use high-Z nanoparticles. It does not establish an exhaustive list of the works in this field but rather propose constructive criticisms pointing out critical factors that could improve the nano-radiation therapy. Whereas most reviews show the chemists and/or biologists points of view, the present analysis is also seen through the prism of the medical physicist. In particular, we described and evaluated the influence of X-rays energy spectra using a numerical analysis. We observed a lack of standardization in preclinical studies that could partially explain the low number of translation to clinical applications for this innovative therapeutic strategy. Pointing out the critical parameters of high-Z nanoparticles radiosensitization, this review is expected to contribute to a larger preclinical and clinical development.
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