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10.1155/2015/659378 http://scihub22266oqcxt.onion/10.1155/2015/659378 C4493306!4493306!26199461     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mediators+Inflamm 2015 ; 2015 (ä): ä Nephropedia Template TP {{tp|p=26199461|t=2015. Tissue Transglutaminase-Regulated Transformed Growth Factor-?1 in the Parasite Links Schistosoma japonicum Infection with Liver Fibrosis |pdf=|usr=}}{{26199461}} gab.com Text Tissue Transglutaminase-Regulated Transformed Growth Factor- 1 in the Parasite Links Schistosoma japonicum Infection with Liver Fibrosis JO: Mediators Inflamm http://www.kidney.de/pget.php?&tw=1&pmid=26199461 #FOAvip Transforming growth factor (TGF-?1) is among the strongest factors of liver fibrogenesis, but its association with Schistosoma-caused liver fibrosis is controversial. Tissue transglutaminase (tTG) is the principal enzyme controlling TGF-?1 maturation and contributes to Sj-infected liver fibrosis. Here we aim to explore the consistency between tTG and TGF-?1 and TGF-?1 source and its correlation with liver fibrosis after Sj-infection. TGF-?1 was upregulated at weeks 6 and 8 upon liver fibrosis induction. During tTG inhibition, TGF-?1 level decreased in sera and liver of infected mice. TGF-?1 showed positive staining in liver containing Sj adult worms and eggs. TGF-?1 was also detected in Sj adult worm sections, soluble egg antigen and Sj adult worm antigen, and adult worms' culture medium. The TGF-?1 mature peptide cDNA sequence and its extended sequence were amplified through RT-PCR and RACE-PCR using adult worms as template, and sequence is analyzed and loaded to NCBI GenBank (number GQ338152.1). TGF-?1 transcript in Sj eggs was higher than in adult worms. In Sj-infected liver, transcriptional level of TGF-?1 from Sj, but not mouse liver, correlated with liver fibrosis extent. This study provides evidence that tTG regulates TGF-?1 and illustrates the importance of targeting tTG in treating Sj infection-induced fibrosis. Twit Text FOAVip Tissue Transglutaminase-Regulated Transformed Growth Factor- 1 in the Parasite Links Schistosoma japonicum Infection with Liver Fibrosis ????Mediators Inflamm http://www.kidney.de/pget.php?&tw=1&pmid=26199461 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26199461 #FOAvip English Wikipedia <ref>{{Cite pmid|26199461}}</ref> Tissue Transglutaminase-Regulated Transformed Growth Factor-?1 in the Parasite Links Schistosoma japonicum Infection with Liver Fibrosis #MMPMID26199461 Tang J; Zhu X; Zhao J; Fung M; Li Y; Gao Z; Yan S; Li X; Ji X; Su F; Li Z Mediators Inflamm 2015[]; 2015 (ä): ä PMID26199461show ga Transforming growth factor (TGF-?1) is among the strongest factors of liver fibrogenesis, but its association with Schistosoma-caused liver fibrosis is controversial. Tissue transglutaminase (tTG) is the principal enzyme controlling TGF-?1 maturation and contributes to Sj-infected liver fibrosis. Here we aim to explore the consistency between tTG and TGF-?1 and TGF-?1 source and its correlation with liver fibrosis after Sj-infection. TGF-?1 was upregulated at weeks 6 and 8 upon liver fibrosis induction. During tTG inhibition, TGF-?1 level decreased in sera and liver of infected mice. TGF-?1 showed positive staining in liver containing Sj adult worms and eggs. TGF-?1 was also detected in Sj adult worm sections, soluble egg antigen and Sj adult worm antigen, and adult worms' culture medium. The TGF-?1 mature peptide cDNA sequence and its extended sequence were amplified through RT-PCR and RACE-PCR using adult worms as template, and sequence is analyzed and loaded to NCBI GenBank (number GQ338152.1). TGF-?1 transcript in Sj eggs was higher than in adult worms. In Sj-infected liver, transcriptional level of TGF-?1 from Sj, but not mouse liver, correlated with liver fibrosis extent. This study provides evidence that tTG regulates TGF-?1 and illustrates the importance of targeting tTG in treating Sj infection-induced fibrosis. äTissue Transglutaminase-Regulated Transformed Growth Factor-?1 in the (epmc).pdf DeepDyve Pubget Overpricing