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10.1038/cr.2015.69 http://scihub22266oqcxt.onion/10.1038/cr.2015.69 C4493278!4493278!26045165     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Res 2015 ; 25 (7): 801-17 Nephropedia Template TP {{tp|p=26045165|t=2015. Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway |pdf=|usr=}}{{26045165}} gab.com Text Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway JO: Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=26045165 #FOAvip The tumor suppressor Merlin/NF2 functions upstream of the core Hippo pathway kinases Lats1/2 and Mst1/2, as well as the nuclear E3 ubiquitin ligase CRL4DCAF1. Numerous mutations of Merlin have been identified in Neurofibromatosis type 2 and other cancer patients. Despite more than two decades of research, the upstream regulator of Merlin in the Hippo pathway remains unknown. Here we show by high-resolution crystal structures that the Lats1/2-binding site on the Merlin FERM domain is physically blocked by Merlin's auto-inhibitory tail. Angiomotin binding releases the auto-inhibition and promotes Merlin's binding to Lats1/2. Phosphorylation of Ser518 outside the Merlin's auto-inhibitory tail does not obviously alter Merlin's conformation, but instead prevents angiomotin from binding and thus inhibits Hippo pathway kinase activation. Cancer-causing mutations clustered in the angiomotin-binding domain impair angiomotin-mediated Merlin activation. Our findings reveal that angiomotin and Merlin respectively interface cortical actin filaments and core kinases in Hippo signaling, and allow construction of a complete Hippo signaling pathway. Twit Text FOAVip Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway ????Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=26045165 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26045165 #FOAvip English Wikipedia <ref>{{Cite pmid|26045165}}</ref> Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway #MMPMID26045165 Li Y; Zhou H; Li F; Chan SW; Lin Z; Wei Z; Yang Z; Guo F; Lim CJ; Xing W; Shen Y; Hong W; Long J; Zhang M Cell Res 2015[Jul]; 25 (7): 801-17 PMID26045165show ga The tumor suppressor Merlin/NF2 functions upstream of the core Hippo pathway kinases Lats1/2 and Mst1/2, as well as the nuclear E3 ubiquitin ligase CRL4DCAF1. Numerous mutations of Merlin have been identified in Neurofibromatosis type 2 and other cancer patients. Despite more than two decades of research, the upstream regulator of Merlin in the Hippo pathway remains unknown. Here we show by high-resolution crystal structures that the Lats1/2-binding site on the Merlin FERM domain is physically blocked by Merlin's auto-inhibitory tail. Angiomotin binding releases the auto-inhibition and promotes Merlin's binding to Lats1/2. Phosphorylation of Ser518 outside the Merlin's auto-inhibitory tail does not obviously alter Merlin's conformation, but instead prevents angiomotin from binding and thus inhibits Hippo pathway kinase activation. Cancer-causing mutations clustered in the angiomotin-binding domain impair angiomotin-mediated Merlin activation. Our findings reveal that angiomotin and Merlin respectively interface cortical actin filaments and core kinases in Hippo signaling, and allow construction of a complete Hippo signaling pathway. äAngiomotin binding-induced activation of Merlin/NF2 in the Hippo pathw(epmc).pdf DeepDyve Pubget Overpricing