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2015 ; 2015
(ä): ä Nephropedia Template TP
gab.com Text
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English Wikipedia
Acute necrotising pancreatitis derived from low-dose corticosteroid use: an
important reminder of clinical management
#MMPMID26150628
Sabre A
; Guthrie MM
; Maleknia R
BMJ Case Rep
2015[Jul]; 2015
(ä): ä PMID26150628
show ga
Although the exact mechanism is unknown, incidence of drug-induced pancreatitis
from corticosteroids is well established in the medical literature. Commonly
reported in chronic steroid-dependent individuals who require large doses for a
wide array of pathologies, the incidence of damage to the pancreas from low-doses
have not been well described. We report a case of a 68-year-old woman who
presented with severe abdominal pain, nausea and vomiting, 3 days after the
initiation of low-dose methylprednisolone for osteoarthritis. Inpatient
laboratory analysis revealed an elevated lipase of 1770 U/L and CT scan showing
extensive necrotising pancreatitis involving the head, body and tail. Cessation
of the causative medication and conservative treatment successfully led to
resolution of symptoms. We present this case to inform clinicians of the
precipitance of pancreatitis from modest strength corticosteroid management, so
that more accurate and improved performance in pharmacological decisions can be
made for patient care.
|Abdominal Pain/diagnosis/etiology
[MESH]
|Adrenal Cortex Hormones/administration & dosage/adverse effects/therapeutic use
[MESH]
|Aged
[MESH]
|Disease Management
[MESH]
|Female
[MESH]
|Glucocorticoids/administration & dosage/*adverse effects/therapeutic use
[MESH]
|Humans
[MESH]
|Lipase/blood
[MESH]
|Methylprednisolone/administration & dosage/*adverse effects/therapeutic use
[MESH]