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2015 ; 10
(6
): 955-65
Nephropedia Template TP
gab.com Text
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English Wikipedia
Composition, structure and function of the Helicobacter pylori cag pathogenicity
island encoded type IV secretion system
#MMPMID26059619
Backert S
; Tegtmeyer N
; Fischer W
Future Microbiol
2015[]; 10
(6
): 955-65
PMID26059619
show ga
Many Gram-negative pathogens harbor type IV secretion systems (T4SS) that
translocate bacterial virulence factors into host cells to hijack cellular
processes. The pathology of the gastric pathogen Helicobacter pylori strongly
depends on a T4SS encoded by the cag pathogenicity island. This T4SS forms a
needle-like pilus, and its assembly is accomplished by multiple protein-protein
interactions and various pilus-associated factors that bind to integrins followed
by delivery of the CagA oncoprotein into gastric epithelial cells. Recent studies
revealed the crystal structures of six T4SS proteins and pilus formation is
modulated by iron and zinc availability. All these T4SS interactions are crucial
for deregulating host signaling events and disease progression. New developments
in T4SS functions and their importance for pathogenesis are discussed.