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10.1038/nsmb.2982 http://scihub22266oqcxt.onion/10.1038/nsmb.2982 C4492989!4492989 !25730776     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25730776 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Struct+Mol+Biol 2015 ; 22 (4 ): 319-27 Nephropedia Template TP {{tp|p=25730776 |t=2015. Microprocessor mediates transcriptional termination of long noncoding RNA transcripts hosting microRNAs |pdf=|usr=}}{{25730776 }} gab.com Text Microprocessor mediates transcriptional termination of long noncoding RNA transcripts hosting microRNAs JO: Nat Struct Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=25730776 #FOAvip MicroRNAs (miRNAs) play a major part in the post-transcriptional regulation of gene expression. Mammalian miRNA biogenesis begins with cotranscriptional cleavage of RNA polymerase II (Pol II) transcripts by the Microprocessor complex. Although most miRNAs are located within introns of protein-coding transcripts, a substantial minority of miRNAs originate from long noncoding (lnc) RNAs, for which transcript processing is largely uncharacterized. We show, by detailed characterization of liver-specific lnc-pri-miR-122 and genome-wide analysis in human cell lines, that most lncRNA transcripts containing miRNAs (lnc-pri-miRNAs) do not use the canonical cleavage-and-polyadenylation pathway but instead use Microprocessor cleavage to terminate transcription. Microprocessor inactivation leads to extensive transcriptional readthrough of lnc-pri-miRNA and transcriptional interference with downstream genes. Consequently we define a new RNase III-mediated, polyadenylation-independent mechanism of Pol II transcription termination in mammalian cells. Twit Text FOAVip Microprocessor mediates transcriptional termination of long noncoding RNA transcripts hosting microRNAs ????Nat Struct Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=25730776 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25730776 #FOAvip English Wikipedia <ref>{{Cite pmid|25730776 }}</ref> Microprocessor mediates transcriptional termination of long noncoding RNA transcripts hosting microRNAs #MMPMID25730776 Dhir A ; Dhir S ; Proudfoot NJ ; Jopling CL Nat Struct Mol Biol 2015[Apr]; 22 (4 ): 319-27 PMID25730776 show ga MicroRNAs (miRNAs) play a major part in the post-transcriptional regulation of gene expression. Mammalian miRNA biogenesis begins with cotranscriptional cleavage of RNA polymerase II (Pol II) transcripts by the Microprocessor complex. Although most miRNAs are located within introns of protein-coding transcripts, a substantial minority of miRNAs originate from long noncoding (lnc) RNAs, for which transcript processing is largely uncharacterized. We show, by detailed characterization of liver-specific lnc-pri-miR-122 and genome-wide analysis in human cell lines, that most lncRNA transcripts containing miRNAs (lnc-pri-miRNAs) do not use the canonical cleavage-and-polyadenylation pathway but instead use Microprocessor cleavage to terminate transcription. Microprocessor inactivation leads to extensive transcriptional readthrough of lnc-pri-miRNA and transcriptional interference with downstream genes. Consequently we define a new RNase III-mediated, polyadenylation-independent mechanism of Pol II transcription termination in mammalian cells. |*Models, Genetic [MESH] |*RNA Processing, Post-Transcriptional [MESH] |*Transcription, Genetic [MESH] |Gene Expression Regulation [MESH] |HeLa Cells [MESH] |Humans [MESH] |MicroRNAs/chemistry/*metabolism [MESH]Microprocessor mediates transcriptional termination of long noncoding (epmc).pdf DeepDyve Pubget Overpricing