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10.1038/nm.3793 http://scihub22266oqcxt.onion/10.1038/nm.3793 C4492683!4492683!25654603     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Med 2015 ; 21 (2): 121-31 Nephropedia Template TP {{tp|p=25654603|t=2015. Therapeutic Genome Editing: Prospects and Challenges |pdf=|usr=}}{{25654603}} gab.com Text Therapeutic Genome Editing: Prospects and Challenges JO: Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=25654603 #FOAvip Recent advances in the development of genome editing technologies based on programmable nucleases have significantly improved our ability to make precise changes in the genomes of eukaryotic cells. Genome editing is already broadening our ability to elucidate the contribution of genetics to disease by facilitating the creation of more accurate cellular and animal models of pathological processes. A particularly tantalizing application of programmable nucleases is the potential to directly correct genetic mutations in affected tissues and cells to treat diseases that are refractory to traditional therapies. Here we discuss current progress towards developing programmable nuclease-based therapies as well as future prospects and challenges. Twit Text FOAVip Therapeutic Genome Editing: Prospects and Challenges ????Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=25654603 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25654603 #FOAvip English Wikipedia <ref>{{Cite pmid|25654603}}</ref> Therapeutic Genome Editing: Prospects and Challenges #MMPMID25654603 Cox DBT; Platt RJ; Zhang F Nat Med 2015[Feb]; 21 (2): 121-31 PMID25654603show ga Recent advances in the development of genome editing technologies based on programmable nucleases have significantly improved our ability to make precise changes in the genomes of eukaryotic cells. Genome editing is already broadening our ability to elucidate the contribution of genetics to disease by facilitating the creation of more accurate cellular and animal models of pathological processes. A particularly tantalizing application of programmable nucleases is the potential to directly correct genetic mutations in affected tissues and cells to treat diseases that are refractory to traditional therapies. Here we discuss current progress towards developing programmable nuclease-based therapies as well as future prospects and challenges. äTherapeutic Genome Editing: Prospects and Challenges (epmc).pdf DeepDyve Pubget Overpricing