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10.1016/j.cell.2012.05.041 http://scihub22266oqcxt.onion/10.1016/j.cell.2012.05.041 C4492542!4492542!22817897     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2012 ; 150 (2): 351-65 Nephropedia Template TP {{tp|p=22817897|t=2012. Noncanonical Wnt Signaling Maintains Hematopoietic Stem Cells in the Niche |pdf=|usr=}}{{22817897}} gab.com Text Noncanonical Wnt Signaling Maintains Hematopoietic Stem Cells in the Niche JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=22817897 #FOAvip Wnt signaling is involved in self-renewal and maintenance of hematopoietic stem cells (HSCs); however, the particular role of noncanonical Wnt signaling in regulating HSCs in vivo is largely unknown. Here, we show Flamingo (Fmi) and Frizzled (Fz) 8, members of noncanonical Wnt signaling, both express in and functionally maintain quiescent long-term HSCs. Fmi regulates Fz8 distribution at the interface between HSCs and N-cadherin+ osteoblasts (N-cad+OBs that enrich osteoprogenitors) in the niche. We further found that N-cad+OBs predominantly express noncanonical Wnt ligands and inhibitors of canonical Wnt signaling under homeostasis. Under stress, noncanonical Wnt signaling is attenuated and canonical Wnt signaling is enhanced in activation of HSCs. Mechanistically, noncanonical Wnt signaling mediated by Fz8 suppresses the Ca2+-NFAT- IFN? pathway, directly or indirectly through the CDC42-CK1? complex and also antagonizes canonical Wnt signaling in HSCs. Taken together, our findings demonstrate that noncanonical Wnt signaling maintains quiescent long-term HSCs through Fmi and Fz8 interaction in the niche. Twit Text FOAVip Noncanonical Wnt Signaling Maintains Hematopoietic Stem Cells in the Niche ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=22817897 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22817897 #FOAvip English Wikipedia <ref>{{Cite pmid|22817897}}</ref> Noncanonical Wnt Signaling Maintains Hematopoietic Stem Cells in the Niche #MMPMID22817897 Sugimura R; He XC; Venkatraman A; Arai F; Box A; Semerad C; Haug JS; Peng L; Zhong Xb; Suda T; Li L Cell 2012[Jul]; 150 (2): 351-65 PMID22817897show ga Wnt signaling is involved in self-renewal and maintenance of hematopoietic stem cells (HSCs); however, the particular role of noncanonical Wnt signaling in regulating HSCs in vivo is largely unknown. Here, we show Flamingo (Fmi) and Frizzled (Fz) 8, members of noncanonical Wnt signaling, both express in and functionally maintain quiescent long-term HSCs. Fmi regulates Fz8 distribution at the interface between HSCs and N-cadherin+ osteoblasts (N-cad+OBs that enrich osteoprogenitors) in the niche. We further found that N-cad+OBs predominantly express noncanonical Wnt ligands and inhibitors of canonical Wnt signaling under homeostasis. Under stress, noncanonical Wnt signaling is attenuated and canonical Wnt signaling is enhanced in activation of HSCs. Mechanistically, noncanonical Wnt signaling mediated by Fz8 suppresses the Ca2+-NFAT- IFN? pathway, directly or indirectly through the CDC42-CK1? complex and also antagonizes canonical Wnt signaling in HSCs. Taken together, our findings demonstrate that noncanonical Wnt signaling maintains quiescent long-term HSCs through Fmi and Fz8 interaction in the niche. äNoncanonical Wnt Signaling Maintains Hematopoietic Stem Cells in the N(epmc).pdf DeepDyve Pubget Overpricing