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2015 ; 123
(7
): 643-50
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Bisphenol S and F: A Systematic Review and Comparison of the Hormonal Activity of
Bisphenol A Substitutes
#MMPMID25775505
Rochester JR
; Bolden AL
Environ Health Perspect
2015[Jul]; 123
(7
): 643-50
PMID25775505
show ga
BACKGROUND: Increasing concern over bisphenol A (BPA) as an endocrine-disrupting
chemical and its possible effects on human health have prompted the removal of
BPA from consumer products, often labeled "BPA-free." Some of the chemical
replacements, however, are also bisphenols and may have similar physiological
effects in organisms. Bisphenol S (BPS) and bisphenol F (BPF) are two such BPA
substitutes. OBJECTIVES: This review was carried out to evaluate the
physiological effects and endocrine activities of the BPA substitutes BPS and
BPF. Further, we compared the hormonal potency of BPS and BPF to that of BPA.
METHODS: We conducted a systematic review based on the Office of Health
Assessment and Translation (OHAT) protocol. RESULTS: We identified the body of
literature to date, consisting of 32 studies (25 in vitro only, and 7 in vivo).
The majority of these studies examined the hormonal activities of BPS and BPF and
found their potency to be in the same order of magnitude and of similar action as
BPA (estrogenic, antiestrogenic, androgenic, and antiandrogenic) in vitro and in
vivo. BPS also has potencies similar to that of estradiol in membrane-mediated
pathways, which are important for cellular actions such as proliferation,
differentiation, and death. BPS and BPF also showed other effects in vitro and in
vivo, such as altered organ weights, reproductive end points, and enzyme
expression. CONCLUSIONS: Based on the current literature, BPS and BPF are as
hormonally active as BPA, and they have endocrine-disrupting effects. CITATION:
Rochester JR, Bolden AL. 2015. Bisphenol S and F: a systematic review and
comparison of the hormonal activity of bisphenol A substitutes.