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10.15252/embj.201490881 http://scihub22266oqcxt.onion/10.15252/embj.201490881 C4491994!4491994 !25759216     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25759216 &cmd=llinks): Failed to open stream: HTTP request failed! 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Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium |pdf=|usr=}}{{25759216 }} gab.com Text Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=25759216 #FOAvip Snail family members regulate epithelial-to-mesenchymal transition (EMT) during invasion of intestinal tumours, but their role in normal intestinal homeostasis is unknown. Studies in breast and skin epithelia indicate that Snail proteins promote an undifferentiated state. Here, we demonstrate that conditional knockout of Snai1 in the intestinal epithelium results in apoptotic loss of crypt base columnar stem cells and bias towards differentiation of secretory lineages. In vitro organoid cultures derived from Snai1 conditional knockout mice also undergo apoptosis when Snai1 is deleted. Conversely, ectopic expression of Snai1 in the intestinal epithelium in vivo results in the expansion of the crypt base columnar cell pool and a decrease in secretory enteroendocrine and Paneth cells. Following conditional deletion of Snai1, the intestinal epithelium fails to produce a proliferative response following radiation-induced damage indicating a fundamental requirement for Snai1 in epithelial regeneration. These results demonstrate that Snai1 is required for regulation of lineage choice, maintenance of CBC stem cells and regeneration of the intestinal epithelium following damage. Twit Text FOAVip Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=25759216 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25759216 #FOAvip English Wikipedia <ref>{{Cite pmid|25759216 }}</ref> Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium #MMPMID25759216 Horvay K ; Jardé T ; Casagranda F ; Perreau VM ; Haigh K ; Nefzger CM ; Akhtar R ; Gridley T ; Berx G ; Haigh JJ ; Barker N ; Polo JM ; Hime GR ; Abud HE EMBO J 2015[May]; 34 (10 ): 1319-35 PMID25759216 show ga Snail family members regulate epithelial-to-mesenchymal transition (EMT) during invasion of intestinal tumours, but their role in normal intestinal homeostasis is unknown. Studies in breast and skin epithelia indicate that Snail proteins promote an undifferentiated state. Here, we demonstrate that conditional knockout of Snai1 in the intestinal epithelium results in apoptotic loss of crypt base columnar stem cells and bias towards differentiation of secretory lineages. In vitro organoid cultures derived from Snai1 conditional knockout mice also undergo apoptosis when Snai1 is deleted. Conversely, ectopic expression of Snai1 in the intestinal epithelium in vivo results in the expansion of the crypt base columnar cell pool and a decrease in secretory enteroendocrine and Paneth cells. Following conditional deletion of Snai1, the intestinal epithelium fails to produce a proliferative response following radiation-induced damage indicating a fundamental requirement for Snai1 in epithelial regeneration. These results demonstrate that Snai1 is required for regulation of lineage choice, maintenance of CBC stem cells and regeneration of the intestinal epithelium following damage. |Animals [MESH] |Apoptosis/genetics/physiology [MESH] |Cell Differentiation/genetics/physiology [MESH] |Cell Lineage [MESH] |Intestinal Mucosa/*metabolism [MESH] |Intestines/*cytology [MESH] |Membrane Glycoproteins/genetics/metabolism [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Signal Transduction/genetics/physiology [MESH] |Snail Family Transcription Factors [MESH]Snai1 regulates cell lineage allocation and stem cell maintenance in t(epmc).pdf DeepDyve Pubget Overpricing