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10.1146/annurev-immunol-032414-112103 http://scihub22266oqcxt.onion/10.1146/annurev-immunol-032414-112103 C4491918!4491918!25594431     free     free     free       Annu+Rev+Immunol 2015 ; 33 (ä): 355-91 Nephropedia Template TP {{tp|p=25594431|t=2015. TAM Receptor Signaling in Immune Homeostasis |pdf=|usr=}}{{25594431}} gab.com Text TAM Receptor Signaling in Immune Homeostasis JO: Annu Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25594431 #FOAvip The TAM receptor tyrosine kinases (RTKs)?TYRO3, AXL, and MERTK?together with their cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation. Deficiencies in TAM signaling have been associated with chronic inflammatory and autoimmune diseases. Three processes regulated by TAM signaling may contribute, either independently or collectively, to immune homeostasis: the negative regulation of the innate immune response, the phagocytosis of apoptotic cells, and the restoration of vascular integrity. Recent studies have also revealed the function of TAMs in infectious diseases and cancer. Here, we review the important milestones in the discovery of these RTKs and their ligands and the studies that underscore the functional importance of this signaling pathway in physiological immune settings and disease. Twit Text FOAVip TAM Receptor Signaling in Immune Homeostasis ????Annu Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25594431 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25594431 #FOAvip English Wikipedia <ref>{{Cite pmid|25594431}}</ref> TAM Receptor Signaling in Immune Homeostasis #MMPMID25594431 Rothlin CV; Carrera-Silva EA; Bosurgi L; Ghosh S Annu Rev Immunol 2015[]; 33 (ä): 355-91 PMID25594431show ga The TAM receptor tyrosine kinases (RTKs)?TYRO3, AXL, and MERTK?together with their cognate agonists GAS6 and PROS1 play an essential role in the resolution of inflammation. Deficiencies in TAM signaling have been associated with chronic inflammatory and autoimmune diseases. Three processes regulated by TAM signaling may contribute, either independently or collectively, to immune homeostasis: the negative regulation of the innate immune response, the phagocytosis of apoptotic cells, and the restoration of vascular integrity. Recent studies have also revealed the function of TAMs in infectious diseases and cancer. Here, we review the important milestones in the discovery of these RTKs and their ligands and the studies that underscore the functional importance of this signaling pathway in physiological immune settings and disease. äTAM Receptor Signaling in Immune Homeostasis (epmc).pdf DeepDyve Pubget Overpricing