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10.4254/wjh.v7.i13.1772 http://scihub22266oqcxt.onion/10.4254/wjh.v7.i13.1772 C4491906!4491906!26167250     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       World+J+Hepatol 2015 ; 7 (13): 1772-81 Nephropedia Template TP {{tp|p=26167250|t=2015. Relevance of ADAMTS13 to liver transplantation and surgery |pdf=|usr=}}{{26167250}} gab.com Text Relevance of ADAMTS13 to liver transplantation and surgery JO: World J Hepatol http://www.kidney.de/pget.php?&tw=1&pmid=26167250 #FOAvip A disintegrin-like and metalloproteinase with thrombospondin type-1 motifs 13 (ADAMTS13) specifically cleaves unusually-large von Willebrand factor (VWF) multimers under high shear stress, and down-regulates VWF function to form platelet thrombi. Deficiency of plasma ADAMTS13 activity induces a life-threatening systemic disease, termed thrombotic microangiopathy (TMA) including thrombotic thrombocytopenic purpura (TTP). Children with advanced biliary cirrhosis due to congenital biliary atresia sometimes showed pathological features of TMA, with a concomitant decrease of plasma ADAMTS13 activity. Disappearance of their clinical findings of TTP after successful liver transplantation suggested that the liver is a major organ producing plasma ADAMTS13. In situ hybridization analysis showed that ADAMTS13 was produced by hepatic stellate cells. Subsequently, it was found that ADADTS13 was not merely responsible to development of TMA and TTP, but also related to some kinds of liver dysfunction after liver transplantation. Ischemia-reperfusion injury and acute rejection in liver transplant recipients were often associated with marked decrease of ADAMTS13 and concomitant formation of unusually large VWF multimers without findings of TMA/TTP. The similar phenomenon was observed also in patients who underwent hepatectomy for liver tumors. Imbalance between ADAMTS13 and VWF in the hepatic sinusoid might cause liver damage due to microcirculatory disturbance. It can be called as ?local TTP like mechanism? which plays a crucial role in liver dysfunction after liver transplantation and surgery. Twit Text FOAVip Relevance of ADAMTS13 to liver transplantation and surgery ????World J Hepatol http://www.kidney.de/pget.php?&tw=1&pmid=26167250 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26167250 #FOAvip English Wikipedia <ref>{{Cite pmid|26167250}}</ref> Relevance of ADAMTS13 to liver transplantation and surgery #MMPMID26167250 Ko S; Chisuwa H; Matsumoto M; Fujimura Y; Okano E; Nakajima Y World J Hepatol 2015[Jul]; 7 (13): 1772-81 PMID26167250show ga A disintegrin-like and metalloproteinase with thrombospondin type-1 motifs 13 (ADAMTS13) specifically cleaves unusually-large von Willebrand factor (VWF) multimers under high shear stress, and down-regulates VWF function to form platelet thrombi. Deficiency of plasma ADAMTS13 activity induces a life-threatening systemic disease, termed thrombotic microangiopathy (TMA) including thrombotic thrombocytopenic purpura (TTP). Children with advanced biliary cirrhosis due to congenital biliary atresia sometimes showed pathological features of TMA, with a concomitant decrease of plasma ADAMTS13 activity. Disappearance of their clinical findings of TTP after successful liver transplantation suggested that the liver is a major organ producing plasma ADAMTS13. In situ hybridization analysis showed that ADAMTS13 was produced by hepatic stellate cells. Subsequently, it was found that ADADTS13 was not merely responsible to development of TMA and TTP, but also related to some kinds of liver dysfunction after liver transplantation. Ischemia-reperfusion injury and acute rejection in liver transplant recipients were often associated with marked decrease of ADAMTS13 and concomitant formation of unusually large VWF multimers without findings of TMA/TTP. The similar phenomenon was observed also in patients who underwent hepatectomy for liver tumors. Imbalance between ADAMTS13 and VWF in the hepatic sinusoid might cause liver damage due to microcirculatory disturbance. It can be called as ?local TTP like mechanism? which plays a crucial role in liver dysfunction after liver transplantation and surgery. äRelevance of ADAMTS13 to liver transplantation and surgery (epmc).pdf DeepDyve Pubget Overpricing