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10.1073/pnas.1424355112 http://scihub22266oqcxt.onion/10.1073/pnas.1424355112 C4491767!4491767!26080408     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (26): 8070-5 Nephropedia Template TP {{tp|p=26080408|t=2015. COX/mPGES-1/PGE2 pathway depicts an inflammatory-dependent high-risk neuroblastoma subset |pdf=|usr=}}{{26080408}} gab.com Text COX/mPGES-1/PGE2 pathway depicts an inflammatory-dependent high-risk neuroblastoma subset JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26080408 #FOAvip Cancer-related inflammation promotes progression and therapy resistance in tumors of adulthood. Knowledge concerning the significance of inflammation in childhood malignancies has been limited. Neuroblastoma is an embryonal tumor of early childhood with poor prognosis despite intensified therapy, and biological understanding is necessary to develop novel therapies. We found high-risk neuroblastoma, in particular the therapy-resistant subset with chromosome 11q-deletion, to be inflammatory driven and characterized by high expression of the COX/microsomal prostaglandin E synthase-1 (mPGES-1)/prostaglandin E2 (PGE2) pathway that correlates with metastatic stage and poor clinical outcome. We further detected infiltrating cancer-associated fibroblasts expressing mPGES-1, the essential enzyme for synthesis of PGE2, promoting tumor growth, angiogenesis, and metastatic spread. Treatment targeting this inflammatory pathway provides a therapeutic option for neuroblastoma and other cancers. Twit Text FOAVip COX/mPGES-1/PGE2 pathway depicts an inflammatory-dependent high-risk neuroblastoma subset ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26080408 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26080408 #FOAvip English Wikipedia <ref>{{Cite pmid|26080408}}</ref> COX/mPGES-1/PGE2 pathway depicts an inflammatory-dependent high-risk neuroblastoma subset #MMPMID26080408 Larsson K; Kock A; Idborg H; Arsenian Henriksson M; Martinsson T; Johnsen JI; Korotkova M; Kogner P; Jakobsson PJ Proc Natl Acad Sci U S A 2015[Jun]; 112 (26): 8070-5 PMID26080408show ga Cancer-related inflammation promotes progression and therapy resistance in tumors of adulthood. Knowledge concerning the significance of inflammation in childhood malignancies has been limited. Neuroblastoma is an embryonal tumor of early childhood with poor prognosis despite intensified therapy, and biological understanding is necessary to develop novel therapies. We found high-risk neuroblastoma, in particular the therapy-resistant subset with chromosome 11q-deletion, to be inflammatory driven and characterized by high expression of the COX/microsomal prostaglandin E synthase-1 (mPGES-1)/prostaglandin E2 (PGE2) pathway that correlates with metastatic stage and poor clinical outcome. We further detected infiltrating cancer-associated fibroblasts expressing mPGES-1, the essential enzyme for synthesis of PGE2, promoting tumor growth, angiogenesis, and metastatic spread. Treatment targeting this inflammatory pathway provides a therapeutic option for neuroblastoma and other cancers. äCOX/mPGES-1/PGE2 pathway depicts an inflammatory-dependent high-risk n(epmc).pdf DeepDyve Pubget Overpricing