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10.3390/cancers7020784 http://scihub22266oqcxt.onion/10.3390/cancers7020784 C4491684!4491684!25985215     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancers+(Basel) 2015 ; 7 (2): 784-94 Nephropedia Template TP {{tp|p=25985215|t=2015. Hedgehog Signaling Inhibitors as Anti-Cancer Agents in Osteosarcoma |pdf=|usr=}}{{25985215}} gab.com Text Hedgehog Signaling Inhibitors as Anti-Cancer Agents in Osteosarcoma JO: Cancers (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=25985215 #FOAvip Osteosarcoma is a rare type of cancer associated with a poor clinical outcome. Even though the pathologic characteristics of OS are well established, much remains to be understood, particularly at the molecular signaling level. The molecular mechanisms of osteosarcoma progression and metastases have not yet been fully elucidated and several evolutionary signaling pathways have been found to be linked with osteosarcoma pathogenesis, especially the hedgehog signaling (Hh) pathway. The present review will outline the importance and targeting the hedgehog signaling (Hh) pathway in osteosarcoma tumor biology. Available data also suggest that aberrant Hh signaling has pro-migratory effects and leads to the development of osteoblastic osteosarcoma. Activation of Hh signaling has been observed in osteosarcoma cell lines and also in primary human osteosarcoma specimens. Emerging data suggests that interference with Hh signal transduction by inhibitors may reduce osteosarcoma cell proliferation and tumor growth thereby preventing osteosarcomagenesis. From this perspective, we outline the current state of Hh pathway inhibitors in osteosarcoma. In summary, targeting Hh signaling by inhibitors promise to increase the efficacy of osteosarcoma treatment and improve patient outcome. Twit Text FOAVip Hedgehog Signaling Inhibitors as Anti-Cancer Agents in Osteosarcoma ????Cancers (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=25985215 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25985215 #FOAvip English Wikipedia <ref>{{Cite pmid|25985215}}</ref> Hedgehog Signaling Inhibitors as Anti-Cancer Agents in Osteosarcoma #MMPMID25985215 Ram Kumar RM; Fuchs B Cancers (Basel) 2015[Jun]; 7 (2): 784-94 PMID25985215show ga Osteosarcoma is a rare type of cancer associated with a poor clinical outcome. Even though the pathologic characteristics of OS are well established, much remains to be understood, particularly at the molecular signaling level. The molecular mechanisms of osteosarcoma progression and metastases have not yet been fully elucidated and several evolutionary signaling pathways have been found to be linked with osteosarcoma pathogenesis, especially the hedgehog signaling (Hh) pathway. The present review will outline the importance and targeting the hedgehog signaling (Hh) pathway in osteosarcoma tumor biology. Available data also suggest that aberrant Hh signaling has pro-migratory effects and leads to the development of osteoblastic osteosarcoma. Activation of Hh signaling has been observed in osteosarcoma cell lines and also in primary human osteosarcoma specimens. Emerging data suggests that interference with Hh signal transduction by inhibitors may reduce osteosarcoma cell proliferation and tumor growth thereby preventing osteosarcomagenesis. From this perspective, we outline the current state of Hh pathway inhibitors in osteosarcoma. In summary, targeting Hh signaling by inhibitors promise to increase the efficacy of osteosarcoma treatment and improve patient outcome. äHedgehog Signaling Inhibitors as Anti-Cancer Agents in Osteosarcoma (epmc).pdf DeepDyve Pubget Overpricing