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10.1038/cti.2015.10 http://scihub22266oqcxt.onion/10.1038/cti.2015.10 C4491623!4491623!26191409     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Transl+Immunology 2015 ; 4 (6): e38- Nephropedia Template TP {{tp|p=26191409|t=2015. B cell-derived circulating granzyme B is a feature of acute infectious mononucleosis |pdf=|usr=}}{{26191409}} gab.com Text B cell-derived circulating granzyme B is a feature of acute infectious mononucleosis JO: Clin Transl Immunology http://www.kidney.de/pget.php?&tw=1&pmid=26191409 #FOAvip Granzyme B (GzmB) is a serine protease best known for inducing target cell apoptosis when released by cytotoxic T lymphocytes (CTLs) or natural killer cells with pore-forming perforin. As a result, GzmB detected in the serum of virus-infected individuals has typically been attributed to these sources. Here, we show that patients with recently diagnosed infectious mononucleosis caused by Epstein-Barr virus (EBV) have high circulating levels of GzmB that may be derived from infected B cells early in course of disease. We recently reported that human B cells from healthy donors secrete active GzmB when stimulated in vitro through B-cell receptor (BCR) ligation and interleukin (IL)-21. We found that infecting B cells with EBV greatly amplified GzmB secretion in response to the same stimuli, but the expression was terminated once the infection had become latent. Our results represent a rare instance of GzmB expression by non-CTL/natural killer cells in the context of infection with a human pathogen. Twit Text FOAVip B cell-derived circulating granzyme B is a feature of acute infectious mononucleosis ????Clin Transl Immunology http://www.kidney.de/pget.php?&tw=1&pmid=26191409 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26191409 #FOAvip English Wikipedia <ref>{{Cite pmid|26191409}}</ref> B cell-derived circulating granzyme B is a feature of acute infectious mononucleosis #MMPMID26191409 Hagn M; Panikkar A; Smith C; Balfour Jr HH; Khanna R; Voskoboinik I; Trapani JA Clin Transl Immunology 2015[Jun]; 4 (6): e38- PMID26191409show ga Granzyme B (GzmB) is a serine protease best known for inducing target cell apoptosis when released by cytotoxic T lymphocytes (CTLs) or natural killer cells with pore-forming perforin. As a result, GzmB detected in the serum of virus-infected individuals has typically been attributed to these sources. Here, we show that patients with recently diagnosed infectious mononucleosis caused by Epstein-Barr virus (EBV) have high circulating levels of GzmB that may be derived from infected B cells early in course of disease. We recently reported that human B cells from healthy donors secrete active GzmB when stimulated in vitro through B-cell receptor (BCR) ligation and interleukin (IL)-21. We found that infecting B cells with EBV greatly amplified GzmB secretion in response to the same stimuli, but the expression was terminated once the infection had become latent. Our results represent a rare instance of GzmB expression by non-CTL/natural killer cells in the context of infection with a human pathogen. äB cell-derived circulating granzyme B is a feature of acute infectious(epmc).pdf DeepDyve Pubget Overpricing