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10.1038/oncsis.2015.17 http://scihub22266oqcxt.onion/10.1038/oncsis.2015.17 C4491612!4491612!26075748     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncogenesis 2015 ; 4 (6): e157- Nephropedia Template TP {{tp|p=26075748|t=2015. An aberrant nuclear localization of E-cadherin is a potent inhibitor of Wnt/?-catenin-elicited promotion of the cancer stem cell phenotype |pdf=|usr=}}{{26075748}} gab.com Text An aberrant nuclear localization of E-cadherin is a potent inhibitor of Wnt/ -catenin-elicited promotion of the cancer stem cell phenotype JO: Oncogenesis http://www.kidney.de/pget.php?&tw=1&pmid=26075748 #FOAvip Several studies suggest that Wnt signaling contributes to reprogramming and maintenance of cancer stem cell (CSC) states activated by loss of membranous E-cadherin expression. However, E-cadherin's exact role in Wnt/?-catenin-mediated promotion of the CSC phenotype remains unclear. Recently, a significant positive correlation has been observed between the expression of nuclear (an aberrant nuclear localization) E-cadherin and ?-catenin in gastric and colorectal carcinomas. Here we conducted a series of in-vitro and in-vivo studies to show that the ?-catenin/TCF4 interaction was abolished by E-cadherin and was correlated with its nuclear localization, and consequently decreased ?-catenin/TCF4 transcriptional activity. Nuclear E-cadherin was a negative regulator of Wnt/?-Catenin-elicited promotion of the CSC phenotype. Using immunohistochemistry on lung cancer tissue microarrays, we found that changes in subcellular location of E-cadherin may be described by tumor grade and stage, suggesting cellular redistribution during lung tumorigenesis. Furthermore, nuclear E-cadherin expression was more significantly inversely correlated with CD133 (a lung CSC marker) expression (P<0.005) than total E-cadherin expression (P<0.05), suggesting that lung cancer as defined by nuclear E-cadherinLow/nuclear ?-cateninHigh/CD133High biomarkers has superior prognostic value over total E-cadherinLow/nuclear ?-cateninHigh/CD133High. Twit Text FOAVip An aberrant nuclear localization of E-cadherin is a potent inhibitor of Wnt/ -catenin-elicited promotion of the cancer stem cell phenotype ????Oncogenesis http://www.kidney.de/pget.php?&tw=1&pmid=26075748 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26075748 #FOAvip English Wikipedia <ref>{{Cite pmid|26075748}}</ref> An aberrant nuclear localization of E-cadherin is a potent inhibitor of Wnt/?-catenin-elicited promotion of the cancer stem cell phenotype #MMPMID26075748 Su YJ; Chang YW; Lin WH; Liang CL; Lee JL Oncogenesis 2015[Jun]; 4 (6): e157- PMID26075748show ga Several studies suggest that Wnt signaling contributes to reprogramming and maintenance of cancer stem cell (CSC) states activated by loss of membranous E-cadherin expression. However, E-cadherin's exact role in Wnt/?-catenin-mediated promotion of the CSC phenotype remains unclear. Recently, a significant positive correlation has been observed between the expression of nuclear (an aberrant nuclear localization) E-cadherin and ?-catenin in gastric and colorectal carcinomas. Here we conducted a series of in-vitro and in-vivo studies to show that the ?-catenin/TCF4 interaction was abolished by E-cadherin and was correlated with its nuclear localization, and consequently decreased ?-catenin/TCF4 transcriptional activity. Nuclear E-cadherin was a negative regulator of Wnt/?-Catenin-elicited promotion of the CSC phenotype. Using immunohistochemistry on lung cancer tissue microarrays, we found that changes in subcellular location of E-cadherin may be described by tumor grade and stage, suggesting cellular redistribution during lung tumorigenesis. Furthermore, nuclear E-cadherin expression was more significantly inversely correlated with CD133 (a lung CSC marker) expression (P<0.005) than total E-cadherin expression (P<0.05), suggesting that lung cancer as defined by nuclear E-cadherinLow/nuclear ?-cateninHigh/CD133High biomarkers has superior prognostic value over total E-cadherinLow/nuclear ?-cateninHigh/CD133High. äAn aberrant nuclear localization of E-cadherin is a potent inhibitor o(epmc).pdf DeepDyve Pubget Overpricing