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10.1038/ncomms8490 http://scihub22266oqcxt.onion/10.1038/ncomms8490 C4491191!4491191!26123524     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2015 ; 6 (ä): ä Nephropedia Template TP {{tp|p=26123524|t=2015. PPL2ab neurons restore sexual responses in aged Drosophila males through dopamine |pdf=|usr=}}{{26123524}} gab.com Text PPL2ab neurons restore sexual responses in aged Drosophila males through dopamine JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26123524 #FOAvip Male sexual desire typically declines with ageing. However, our understanding of the neurobiological basis for this phenomenon is limited by our knowledge of the brain circuitry and neuronal pathways controlling male sexual desire. A number of studies across species suggest that dopamine (DA) affects sexual desire. Here we use genetic tools and behavioural assays to identify a novel subset of DA neurons that regulate age-associated male courtship activity in Drosophila. We find that increasing DA levels in a subset of cells in the PPL2ab neuronal cluster is necessary and sufficient for increased sustained courtship in both young and aged male flies. Our results indicate that preventing the age-related decline in DA levels in PPL2ab neurons alleviates diminished courtship behaviours in male Drosophila. These results may provide the foundation for deciphering the circuitry involved in sexual motivation in the male Drosophila brain. Twit Text FOAVip PPL2ab neurons restore sexual responses in aged Drosophila males through dopamine ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26123524 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26123524 #FOAvip English Wikipedia <ref>{{Cite pmid|26123524}}</ref> PPL2ab neurons restore sexual responses in aged Drosophila males through dopamine #MMPMID26123524 Kuo SY; Wu CL; Hsieh MY; Lin CT; Wen RK; Chen LC; Chen YH; Yu YW; Wang HD; Su YJ; Lin CJ; Yang CY; Guan HY; Wang PY; Lan TH; Fu TF Nat Commun 2015[]; 6 (ä): ä PMID26123524show ga Male sexual desire typically declines with ageing. However, our understanding of the neurobiological basis for this phenomenon is limited by our knowledge of the brain circuitry and neuronal pathways controlling male sexual desire. A number of studies across species suggest that dopamine (DA) affects sexual desire. Here we use genetic tools and behavioural assays to identify a novel subset of DA neurons that regulate age-associated male courtship activity in Drosophila. We find that increasing DA levels in a subset of cells in the PPL2ab neuronal cluster is necessary and sufficient for increased sustained courtship in both young and aged male flies. Our results indicate that preventing the age-related decline in DA levels in PPL2ab neurons alleviates diminished courtship behaviours in male Drosophila. These results may provide the foundation for deciphering the circuitry involved in sexual motivation in the male Drosophila brain. äPPL2ab neurons restore sexual responses in aged Drosophila males throu(epmc).pdf DeepDyve Pubget Overpricing