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2015 ; 19
(3
): 259-65
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English Wikipedia
Tinnitus Neural Mechanisms and Structural Changes in the Brain: The Contribution
of Neuroimaging Research
#MMPMID26157502
Simonetti P
; Oiticica J
Int Arch Otorhinolaryngol
2015[Jul]; 19
(3
): 259-65
PMID26157502
show ga
Introduction?Tinnitus is an abnormal perception of sound in the absence of an
external stimulus. Chronic tinnitus usually has a high impact in many aspects of
patients' lives, such as emotional stress, sleep disturbance, concentration
difficulties, and so on. These strong reactions are usually attributed to central
nervous system involvement. Neuroimaging has revealed the implication of brain
structures in the auditory system. Objective?This systematic review points out
neuroimaging studies that contribute to identifying the structures involved in
the pathophysiological mechanism of generation and persistence of various forms
of tinnitus. Data Synthesis?Functional imaging research reveals that tinnitus
perception is associated with the involvement of the nonauditory brain areas,
including the front parietal area; the limbic system, which consists of the
anterior cingulate cortex, anterior insula, and amygdala; and the hippocampal and
parahippocampal area. Conclusion?The neuroimaging research confirms the
involvement of the mechanisms of memory and cognition in the persistence of
perception, anxiety, distress, and suffering associated with tinnitus.