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10.1038/ncomms6872 http://scihub22266oqcxt.onion/10.1038/ncomms6872 C4490789!4490789 !25519988     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25519988 &cmd=llinks): Failed to open stream: HTTP request failed! 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Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte development |pdf=|usr=}}{{25519988 }} gab.com Text Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte development JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25519988 #FOAvip During T-cell development, Cd8 expression is controlled via dynamic regulation of its cis-regulatory enhancer elements. Insufficiency of enhancer activity causes variegated Cd8 expression in CD4(+)CD8(+) double-positive (DP) thymocytes. Brd1 is a subunit of the Hbo1 histone acetyltransferase (HAT) complex responsible for acetylation of histone H3 at lysine 14 (H3K14). Here we show that deletion of Brd1 in haematopoietic progenitors causes variegated expression of Cd8, resulting in the appearance of CD4(+)CD8(-)TCR?(-/low) thymocytes indistinguishable from DP thymocytes in their properties. Biochemical analysis confirms that Brd1 forms a HAT complex with Hbo1 in thymocytes. ChIP analysis demonstrates that Brd1 localizes at the known enhancers in the Cd8 genes and is responsible for acetylation at H3K14. These findings indicate that the Brd1-mediated HAT activity is crucial for efficient activation of Cd8 expression via acetylation at H3K14, which serves as an epigenetic mark that promotes the recruitment of transcription machinery to the Cd8 enhancers. Twit Text FOAVip Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte development ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25519988 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25519988 #FOAvip English Wikipedia <ref>{{Cite pmid|25519988 }}</ref> Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte development #MMPMID25519988 Mishima Y ; Wang C ; Miyagi S ; Saraya A ; Hosokawa H ; Mochizuki-Kashio M ; Nakajima-Takagi Y ; Koide S ; Negishi M ; Sashida G ; Naito T ; Ishikura T ; Onodera A ; Nakayama T ; Tenen DG ; Yamaguchi N ; Koseki H ; Taniuchi I ; Iwama A Nat Commun 2014[Dec]; 5 (ä): 5872 PMID25519988 show ga During T-cell development, Cd8 expression is controlled via dynamic regulation of its cis-regulatory enhancer elements. Insufficiency of enhancer activity causes variegated Cd8 expression in CD4(+)CD8(+) double-positive (DP) thymocytes. Brd1 is a subunit of the Hbo1 histone acetyltransferase (HAT) complex responsible for acetylation of histone H3 at lysine 14 (H3K14). Here we show that deletion of Brd1 in haematopoietic progenitors causes variegated expression of Cd8, resulting in the appearance of CD4(+)CD8(-)TCR?(-/low) thymocytes indistinguishable from DP thymocytes in their properties. Biochemical analysis confirms that Brd1 forms a HAT complex with Hbo1 in thymocytes. ChIP analysis demonstrates that Brd1 localizes at the known enhancers in the Cd8 genes and is responsible for acetylation at H3K14. These findings indicate that the Brd1-mediated HAT activity is crucial for efficient activation of Cd8 expression via acetylation at H3K14, which serves as an epigenetic mark that promotes the recruitment of transcription machinery to the Cd8 enhancers. |*Epigenesis, Genetic [MESH] |*Protein Processing, Post-Translational [MESH] |Acetylation [MESH] |Animals [MESH] |CD8 Antigens/genetics/*immunology [MESH] |Cell Differentiation [MESH] |Enhancer Elements, Genetic [MESH] |Female [MESH] |Gene Expression Regulation, Developmental [MESH] |Hematopoietic Stem Cells/cytology/immunology [MESH] |Histone Acetyltransferases/deficiency/genetics/*immunology [MESH] |Histones/genetics/immunology [MESH] |Immunity, Innate [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Transgenic [MESH] |Signal Transduction [MESH]Histone acetylation mediated by Brd1 is crucial for Cd8 gene activatio(epmc).pdf DeepDyve Pubget Overpricing