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10.1089/brain.2014.0304

http://scihub22266oqcxt.onion/10.1089/brain.2014.0304
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C4490704!4490704!25492633
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suck abstract from ncbi


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pmid25492633      Brain+Connect 2015 ; 5 (5): 284-91
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  • Brain Graph Topology Changes Associated with Anti-Epileptic Drug Use #MMPMID25492633
  • Haneef Z; Levin HS; Chiang S
  • Brain Connect 2015[Jun]; 5 (5): 284-91 PMID25492633show ga
  • Neuroimaging studies of functional connectivity using graph theory have furthered our understanding of the network structure in temporal lobe epilepsy (TLE). Brain network effects of anti-epileptic drugs could influence such studies, but have not been systematically studied. Resting-state functional MRI was analyzed in 25 patients with TLE using graph theory analysis. Patients were divided into two groups based on anti-epileptic medication use: those taking carbamazepine/oxcarbazepine (CBZ/OXC) (n=9) and those not taking CBZ/OXC (n=16) as a part of their medication regimen. The following graph topology metrics were analyzed: global efficiency, betweenness centrality (BC), clustering coefficient, and small-world index. Multiple linear regression was used to examine the association of CBZ/OXC with graph topology. The two groups did not differ from each other based on epilepsy characteristics. Use of CBZ/OXC was associated with a lower BC. Longer epilepsy duration was also associated with a lower BC. These findings can inform graph theory-based studies in patients with TLE. The changes observed are discussed in relation to the anti-epileptic mechanism of action and adverse effects of CBZ/OXC.
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