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10.1038/ncomms8159 http://scihub22266oqcxt.onion/10.1038/ncomms8159 C4490570!4490570!26074052     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2015 ; 6 (ä): ä Nephropedia Template TP {{tp|p=26074052|t=2015. The tethering of chromatin to the nuclear envelope supports nuclear mechanics |pdf=|usr=}}{{26074052}} gab.com Text The tethering of chromatin to the nuclear envelope supports nuclear mechanics JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26074052 #FOAvip The nuclear lamina is thought to be the primary mechanical defence of the nucleus. However, the lamina is integrated within a network of lipids, proteins and chromatin; the interdependence of this network poses a challenge to defining the individual mechanical contributions of these components. Here, we isolate the role of chromatin in nuclear mechanics by using a system lacking lamins. Using novel imaging analyses, we observe that untethering chromatin from the inner nuclear membrane results in highly deformable nuclei in vivo, particularly in response to cytoskeletal forces. Using optical tweezers, we find that isolated nuclei lacking inner nuclear membrane tethers are less stiff than wild-type nuclei and exhibit increased chromatin flow, particularly in frequency ranges that recapitulate the kinetics of cytoskeletal dynamics. We suggest that modulating chromatin flow can define both transient and long-lived changes in nuclear shape that are biologically important and may be altered in disease. Twit Text FOAVip The tethering of chromatin to the nuclear envelope supports nuclear mechanics ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26074052 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26074052 #FOAvip English Wikipedia <ref>{{Cite pmid|26074052}}</ref> The tethering of chromatin to the nuclear envelope supports nuclear mechanics #MMPMID26074052 Schreiner SM; Koo PK; Zhao Y; Mochrie SGJ; King MC Nat Commun 2015[]; 6 (ä): ä PMID26074052show ga The nuclear lamina is thought to be the primary mechanical defence of the nucleus. However, the lamina is integrated within a network of lipids, proteins and chromatin; the interdependence of this network poses a challenge to defining the individual mechanical contributions of these components. Here, we isolate the role of chromatin in nuclear mechanics by using a system lacking lamins. Using novel imaging analyses, we observe that untethering chromatin from the inner nuclear membrane results in highly deformable nuclei in vivo, particularly in response to cytoskeletal forces. Using optical tweezers, we find that isolated nuclei lacking inner nuclear membrane tethers are less stiff than wild-type nuclei and exhibit increased chromatin flow, particularly in frequency ranges that recapitulate the kinetics of cytoskeletal dynamics. We suggest that modulating chromatin flow can define both transient and long-lived changes in nuclear shape that are biologically important and may be altered in disease. äThe tethering of chromatin to the nuclear envelope supports nuclear me(epmc).pdf DeepDyve Pubget Overpricing