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10.1038/ncomms8439 http://scihub22266oqcxt.onion/10.1038/ncomms8439 C4490561!4490561 !26074490     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26074490 &cmd=llinks): Failed to open stream: HTTP request failed! 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A novel mechanism of generating extracellular vesicles during apoptosis via a beads-on-a-string membrane structure |pdf=|usr=}}{{26074490 }} gab.com Text A novel mechanism of generating extracellular vesicles during apoptosis via a beads-on-a-string membrane structure JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26074490 #FOAvip Disassembly of apoptotic cells into smaller fragments (a form of extracellular vesicle called apoptotic bodies) can facilitate removal of apoptotic debris and intercellular communication. However, the mechanism underpinning this process is unclear. While observing monocytes undergoing apoptosis by time-lapse microscopy, we discovered a new type of membrane protrusion that resembles a 'beads-on-a-string' structure. Strikingly, the 'beads' are frequently sheared off the 'string' to form apoptotic bodies. Generation of apoptotic bodies via this mechanism can facilitate a sorting process and results in the exclusion of nuclear contents from apoptotic bodies. Mechanistically, generation of 'beads-on-a-string' protrusion is controlled by the level of actomyosin contraction and apoptopodia formation. Furthermore, in an unbiased drug screen, we identified the ability of sertraline (an antidepressant) to block the formation of 'beads-on-a-string' protrusions and apoptotic bodies. These data uncover a new mechanism of apoptotic body formation in monocytes and also compounds that can modulate this process. Twit Text FOAVip A novel mechanism of generating extracellular vesicles during apoptosis via a beads-on-a-string membrane structure ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26074490 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26074490 #FOAvip English Wikipedia <ref>{{Cite pmid|26074490 }}</ref> A novel mechanism of generating extracellular vesicles during apoptosis via a beads-on-a-string membrane structure #MMPMID26074490 Atkin-Smith GK ; Tixeira R ; Paone S ; Mathivanan S ; Collins C ; Liem M ; Goodall KJ ; Ravichandran KS ; Hulett MD ; Poon IK Nat Commun 2015[Jun]; 6 (ä): 7439 PMID26074490 show ga Disassembly of apoptotic cells into smaller fragments (a form of extracellular vesicle called apoptotic bodies) can facilitate removal of apoptotic debris and intercellular communication. However, the mechanism underpinning this process is unclear. While observing monocytes undergoing apoptosis by time-lapse microscopy, we discovered a new type of membrane protrusion that resembles a 'beads-on-a-string' structure. Strikingly, the 'beads' are frequently sheared off the 'string' to form apoptotic bodies. Generation of apoptotic bodies via this mechanism can facilitate a sorting process and results in the exclusion of nuclear contents from apoptotic bodies. Mechanistically, generation of 'beads-on-a-string' protrusion is controlled by the level of actomyosin contraction and apoptopodia formation. Furthermore, in an unbiased drug screen, we identified the ability of sertraline (an antidepressant) to block the formation of 'beads-on-a-string' protrusions and apoptotic bodies. These data uncover a new mechanism of apoptotic body formation in monocytes and also compounds that can modulate this process. |*Apoptosis [MESH] |Actomyosin/metabolism [MESH] |Cell Line [MESH] |Cell Membrane/metabolism/*ultrastructure [MESH] |Cell Survival [MESH] |Epithelial Cells/metabolism/*ultrastructure [MESH] |Extracellular Vesicles/metabolism/*ultrastructure [MESH] |HeLa Cells [MESH] |Humans [MESH] |Jurkat Cells [MESH] |Microscopy, Interference [MESH] |Monocytes/metabolism/*ultrastructure [MESH] |Neurons/metabolism/*ultrastructure [MESH]A novel mechanism of generating extracellular vesicles during apoptosi(epmc).pdf DeepDyve Pubget Overpricing