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10.3390/ijms160614086

http://scihub22266oqcxt.onion/10.3390/ijms160614086
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C4490540!4490540!26101867
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suck abstract from ncbi


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pmid26101867      Int+J+Mol+Sci 2015 ; 16 (6): 14086-97
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  • Hepatoma-Derived Growth Factor: Its Possible Involvement in the Progression of Hepatocellular Carcinoma #MMPMID26101867
  • Enomoto H; Nakamura H; Liu W; Nishiguchi S
  • Int J Mol Sci 2015[Jun]; 16 (6): 14086-97 PMID26101867show ga
  • The development of hepatocellular carcinoma (HCC) is an important complication of viral infection induced by hepatitis virus C, and our major research theme is to identify a new growth factor related to the progression of HCC. HDGF (hepatoma-derived growth factor) is a novel growth factor that belongs to a new gene family. HDGF was initially purified from the conditioned medium of a hepatoma cell line. HDGF promotes cellular proliferation as a DNA binding nuclear factor and a secreted protein acting via a receptor-mediated pathway. HDGF is a unique multi-functional protein that can function as a growth factor, angiogenic factor and anti-apoptotic factor and it participates in the development and progression of various malignant diseases. The expression level of HDGF may be an independent prognostic factor for predicting the disease-free and overall survival in patients with various malignancies, including HCC. Furthermore, the overexpression of HDGF promotes the proliferation of HCC cells, while a reduction in the HDGF expression inhibits the proliferation of HCC cells. This article provides an overview of the characteristics of HDGF and describes the potential role of HDGF as a growth-promoting factor for HCC.
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