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Hepatoma-Derived Growth Factor: Its Possible Involvement in the Progression of
Hepatocellular Carcinoma
#MMPMID26101867
Enomoto H
; Nakamura H
; Liu W
; Nishiguchi S
Int J Mol Sci
2015[Jun]; 16
(6
): 14086-97
PMID26101867
show ga
The development of hepatocellular carcinoma (HCC) is an important complication of
viral infection induced by hepatitis virus C, and our major research theme is to
identify a new growth factor related to the progression of HCC. HDGF
(hepatoma-derived growth factor) is a novel growth factor that belongs to a new
gene family. HDGF was initially purified from the conditioned medium of a
hepatoma cell line. HDGF promotes cellular proliferation as a DNA binding nuclear
factor and a secreted protein acting via a receptor-mediated pathway. HDGF is a
unique multi-functional protein that can function as a growth factor, angiogenic
factor and anti-apoptotic factor and it participates in the development and
progression of various malignant diseases. The expression level of HDGF may be an
independent prognostic factor for predicting the disease-free and overall
survival in patients with various malignancies, including HCC. Furthermore, the
overexpression of HDGF promotes the proliferation of HCC cells, while a reduction
in the HDGF expression inhibits the proliferation of HCC cells. This article
provides an overview of the characteristics of HDGF and describes the potential
role of HDGF as a growth-promoting factor for HCC.
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