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10.3390/ijms160613084

http://scihub22266oqcxt.onion/10.3390/ijms160613084
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C4490487!4490487!26068236
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suck abstract from ncbi


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pmid26068236      Int+J+Mol+Sci 2015 ; 16 (6): 13084-105
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  • Roles of B Cell-Intrinsic TLR Signals in Systemic Lupus Erythematosus #MMPMID26068236
  • Ma K; Li J; Fang Y; Lu L
  • Int J Mol Sci 2015[Jun]; 16 (6): 13084-105 PMID26068236show ga
  • Toll-like receptors (TLRs) are a large family of pattern recognition receptors. TLR signals are involved in the pathogenesis of systemic lupus erythematosus. Mouse and human B cells constitutively express most TLRs. Many B cell subpopulations are highly responsive to certain TLR ligation, including B-1 B cells, transitional B cells, marginal zone B cells, germinal center B cell and memory B cells. The B cell-intrinsic TLR signals play critical roles during lupus process. In this review, roles of B cell-intrinsic TLR2, 4, 7, 8 and 9 signals are discussed during lupus pathogenesis in both mouse model and patients. Moreover, mechanisms underlying TLR ligation-triggered B cell activation and signaling pathways are highlighted.
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