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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Int+J+Mol+Sci 2015 ; 16 (6): 12436-53 Nephropedia Template TP
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Circulating Levels of sFlt1 Splice Variants as Predictive Markers for the Development of Preeclampsia #MMPMID26042465
Souders CA; Maynard SE; Yan J; Wang Y; Boatright NK; Sedan J; Balyozian D; Cheslock PS; Molrine DC; Moore Simas TA
Int J Mol Sci 2015[Jun]; 16 (6): 12436-53 PMID26042465show ga
Angiogenic biomarkers, including soluble fms-like tyrosine kinase 1 (sFlt1), are thought to be predictors of preeclampsia onset; however, improvement is needed before a widespread diagnostic test can be utilized. Here we describe the development and use of diagnostic monoclonal antibodies specific to the two main splice variants of sFlt1, sFlt1-1 and sFlt1-14. These antibodies were selected for their sensitivity and specificity to their respective sFlt1 isoform in a capture ELISA format. Data from this pilot study suggest that sFlt1-1 may be more predictive of preeclampsia than total sFlt1. It may be possible to improve current diagnostic platforms if more specific antibodies are utilized.