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10.3390/ijms160612092 http://scihub22266oqcxt.onion/10.3390/ijms160612092 C4490431!4490431 !26023717     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26023717 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Sci 2015 ; 16 (6 ): 12092-107 Nephropedia Template TP {{tp|p=26023717 |t=2015. Anesthetic propofol overdose causes vascular hyperpermeability by reducing endothelial glycocalyx and ATP production |pdf=|usr=}}{{26023717 }} gab.com Text Anesthetic propofol overdose causes vascular hyperpermeability by reducing endothelial glycocalyx and ATP production JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26023717 #FOAvip Prolonged treatment with a large dose of propofol may cause diffuse cellular cytotoxicity; however, the detailed underlying mechanism remains unclear, particularly in vascular endothelial cells. Previous studies showed that a propofol overdose induces endothelial injury and vascular barrier dysfunction. Regarding the important role of endothelial glycocalyx on the maintenance of vascular barrier integrity, we therefore hypothesized that a propofol overdose-induced endothelial barrier dysfunction is caused by impaired endothelial glycocalyx. In vivo, we intraperitoneally injected ICR mice with overdosed propofol, and the results showed that a propofol overdose significantly induced systemic vascular hyperpermeability and reduced the expression of endothelial glycocalyx, syndecan-1, syndecan-4, perlecan mRNA and heparan sulfate (HS) in the vessels of multiple organs. In vitro, a propofol overdose reduced the expression of syndecan-1, syndecan-4, perlecan, glypican-1 mRNA and HS and induced significant decreases in the nicotinamide adenine dinucleotide (NAD+)/NADH ratio and ATP concentrations in human microvascular endothelial cells (HMEC-1). Oligomycin treatment also induced significant decreases in the NAD+/NADH ratio, in ATP concentrations and in syndecan-4, perlecan and glypican-1 mRNA expression in HMEC-1 cells. These results demonstrate that a propofol overdose induces a partially ATP-dependent reduction of endothelial glycocalyx expression and consequently leads to vascular hyperpermeability due to the loss of endothelial barrier functions. Twit Text FOAVip Anesthetic propofol overdose causes vascular hyperpermeability by reducing endothelial glycocalyx and ATP production ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26023717 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26023717 #FOAvip English Wikipedia <ref>{{Cite pmid|26023717 }}</ref> Anesthetic propofol overdose causes vascular hyperpermeability by reducing endothelial glycocalyx and ATP production #MMPMID26023717 Lin MC ; Lin CF ; Li CF ; Sun DP ; Wang LY ; Hsing CH Int J Mol Sci 2015[May]; 16 (6 ): 12092-107 PMID26023717 show ga Prolonged treatment with a large dose of propofol may cause diffuse cellular cytotoxicity; however, the detailed underlying mechanism remains unclear, particularly in vascular endothelial cells. Previous studies showed that a propofol overdose induces endothelial injury and vascular barrier dysfunction. Regarding the important role of endothelial glycocalyx on the maintenance of vascular barrier integrity, we therefore hypothesized that a propofol overdose-induced endothelial barrier dysfunction is caused by impaired endothelial glycocalyx. In vivo, we intraperitoneally injected ICR mice with overdosed propofol, and the results showed that a propofol overdose significantly induced systemic vascular hyperpermeability and reduced the expression of endothelial glycocalyx, syndecan-1, syndecan-4, perlecan mRNA and heparan sulfate (HS) in the vessels of multiple organs. In vitro, a propofol overdose reduced the expression of syndecan-1, syndecan-4, perlecan, glypican-1 mRNA and HS and induced significant decreases in the nicotinamide adenine dinucleotide (NAD+)/NADH ratio and ATP concentrations in human microvascular endothelial cells (HMEC-1). Oligomycin treatment also induced significant decreases in the NAD+/NADH ratio, in ATP concentrations and in syndecan-4, perlecan and glypican-1 mRNA expression in HMEC-1 cells. These results demonstrate that a propofol overdose induces a partially ATP-dependent reduction of endothelial glycocalyx expression and consequently leads to vascular hyperpermeability due to the loss of endothelial barrier functions. |Adenosine Triphosphate/*metabolism [MESH] |Anesthetics/administration & dosage/*toxicity [MESH] |Animals [MESH] |Capillary Permeability/*drug effects [MESH] |Cell Line [MESH] |Cells, Cultured [MESH] |Disease Models, Animal [MESH] |Drug Overdose/etiology/genetics/metabolism/*pathology [MESH] |Endothelial Cells/drug effects [MESH] |Gene Expression Regulation [MESH] |Glycocalyx/*genetics/metabolism [MESH] |Humans [MESH] |Injections, Intraperitoneal [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred ICR [MESH] |Propofol/administration & dosage/*toxicity [MESH]Anesthetic propofol overdose causes vascular hyperpermeability by redu(epmc).pdf DeepDyve Pubget Overpricing