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10.3390/ijms160612051 http://scihub22266oqcxt.onion/10.3390/ijms160612051 C4490428!4490428!26023714     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2015 ; 16 (6): 12051-63 Nephropedia Template TP {{tp|p=26023714|t=2015. 1,8-Cineole Ameliorates Steatosis of Pten Liver Specific KO Mice via Akt Inactivation |pdf=|usr=}}{{26023714}} gab.com Text 1,8-Cineole Ameliorates Steatosis of Pten Liver Specific KO Mice via Akt Inactivation JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26023714 #FOAvip Hepatocyte-specific Phosphatase and tensin homolog (Pten)-knockout (KO) mice exhibit hepatic lesions analogous to non-alcoholic steatohepatitis (NASH). 1,8-cineole is a monoterpene oxide and it has several biological effects including hepatoprotective effects. In this study we revealed that 1,8-cineole ameliorates NASH of Pten KO mice. Pten KO mice were assigned to a control group without any medication or to a 1,8-cineole group injected with 50 mg/kg i.p. twice per week for eight weeks. At eight weeks, livers from each group were processed to measure triglyceride (TG) content, gene expression analysis, western blot analysis, and histological examination including Oil red O staining. 1,8-cineole ameliorated hepatic steatosis in Pten KO mice, revealed by TG content and Oil red O staining. Moreover, 1,8-cineole downregulated collagen 1a1 expression and improved liver fibrosis. Thus, 1,8-cineole has potential as a candidate to treat NASH by inactivating the Akt/PI3-kinase pathway. Twit Text FOAVip 1,8-Cineole Ameliorates Steatosis of Pten Liver Specific KO Mice via Akt Inactivation ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26023714 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26023714 #FOAvip English Wikipedia <ref>{{Cite pmid|26023714}}</ref> 1,8-Cineole Ameliorates Steatosis of Pten Liver Specific KO Mice via Akt Inactivation #MMPMID26023714 Murata S; Ogawa K; Matsuzaka T; Chiba M; Nakayama K; Iwasaki K; Kurokawa T; Sano N; Tanoi T; Ohkohchi N Int J Mol Sci 2015[Jun]; 16 (6): 12051-63 PMID26023714show ga Hepatocyte-specific Phosphatase and tensin homolog (Pten)-knockout (KO) mice exhibit hepatic lesions analogous to non-alcoholic steatohepatitis (NASH). 1,8-cineole is a monoterpene oxide and it has several biological effects including hepatoprotective effects. In this study we revealed that 1,8-cineole ameliorates NASH of Pten KO mice. Pten KO mice were assigned to a control group without any medication or to a 1,8-cineole group injected with 50 mg/kg i.p. twice per week for eight weeks. At eight weeks, livers from each group were processed to measure triglyceride (TG) content, gene expression analysis, western blot analysis, and histological examination including Oil red O staining. 1,8-cineole ameliorated hepatic steatosis in Pten KO mice, revealed by TG content and Oil red O staining. Moreover, 1,8-cineole downregulated collagen 1a1 expression and improved liver fibrosis. Thus, 1,8-cineole has potential as a candidate to treat NASH by inactivating the Akt/PI3-kinase pathway. ä1,8-Cineole Ameliorates Steatosis of Pten Liver Specific KO Mice via A(epmc).pdf DeepDyve Pubget Overpricing