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10.1007/978-3-662-43492-5_9

http://scihub22266oqcxt.onion/10.1007/978-3-662-43492-5_9
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C4489423!4489423!25004819
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suck abstract from ncbi


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pmid25004819      Curr+Top+Microbiol+Immunol 2014 ; 380 (ä): 191-212
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  • The Molecular Basis of IL-10 Function: From Receptor Structure to the Onset of Signaling #MMPMID25004819
  • Walter MR
  • Curr Top Microbiol Immunol 2014[]; 380 (ä): 191-212 PMID25004819show ga
  • Assembly of the cell surface IL-10 receptor complex is the first step in initiating IL-10 signaling pathways that regulate intestinal inflammation, viral persistence, and even tumor surveillance. The discovery of IL-10 homologs in the genomes of herpes viruses suggests IL-10 signaling pathways can be manipulated at the level of the receptor complex. This chapter will describe our current molecular understanding of IL-10 receptor assembly based on crystal structures and biochemical analyses of cellular and viral IL-10 receptor complexes.
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