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10.3389/fimmu.2015.00335 http://scihub22266oqcxt.onion/10.3389/fimmu.2015.00335 C4489332!4489332!26191062     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2015 ; 6 (ä): ä Nephropedia Template TP {{tp|p=26191062|t=2015. Intracellular Transport Routes for MHC I and Their Relevance for Antigen Cross-Presentation |pdf=|usr=}}{{26191062}} gab.com Text Intracellular Transport Routes for MHC I and Their Relevance for Antigen Cross-Presentation JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26191062 #FOAvip Cross-presentation, in which exogenous antigens are presented via MHC I complexes, is involved both in the generation of anti-infectious and anti-tumoral cytotoxic CD8+ T cells and in the maintenance of immune tolerance. While cross-presentation was described almost four decades ago and while it is now established that some dendritic cell (DC) subsets are better than others in processing and cross-presenting internalized antigens, the involved molecular mechanisms remain only partially understood. Some of the least explored molecular mechanisms in cross-presentation concern the origin of cross-presenting MHC I molecules and the cellular compartments where antigenic peptide loading occurs. This review focuses on MHC I molecules and their intracellular trafficking. We discuss the source of cross-presenting MHC I in DCs as well as the role of the endocytic pathway in their recycling from the cell surface. Next, we describe the importance of the TAP peptide transporter for delivering peptides to MHC I during cross-presentation. Finally, we highlight the impact of innate immunity mechanisms on specific antigen cross-presentation mechanisms in which TLR activation modulates MHC I trafficking and TAP localization. Twit Text FOAVip Intracellular Transport Routes for MHC I and Their Relevance for Antigen Cross-Presentation ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26191062 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26191062 #FOAvip English Wikipedia <ref>{{Cite pmid|26191062}}</ref> Intracellular Transport Routes for MHC I and Their Relevance for Antigen Cross-Presentation #MMPMID26191062 Adiko AC; Babdor J; Gutiérrez-Martínez E; Guermonprez P; Saveanu L Front Immunol 2015[]; 6 (ä): ä PMID26191062show ga Cross-presentation, in which exogenous antigens are presented via MHC I complexes, is involved both in the generation of anti-infectious and anti-tumoral cytotoxic CD8+ T cells and in the maintenance of immune tolerance. While cross-presentation was described almost four decades ago and while it is now established that some dendritic cell (DC) subsets are better than others in processing and cross-presenting internalized antigens, the involved molecular mechanisms remain only partially understood. Some of the least explored molecular mechanisms in cross-presentation concern the origin of cross-presenting MHC I molecules and the cellular compartments where antigenic peptide loading occurs. This review focuses on MHC I molecules and their intracellular trafficking. We discuss the source of cross-presenting MHC I in DCs as well as the role of the endocytic pathway in their recycling from the cell surface. Next, we describe the importance of the TAP peptide transporter for delivering peptides to MHC I during cross-presentation. Finally, we highlight the impact of innate immunity mechanisms on specific antigen cross-presentation mechanisms in which TLR activation modulates MHC I trafficking and TAP localization. äIntracellular Transport Routes for MHC I and Their Relevance for Antig(epmc).pdf DeepDyve Pubget Overpricing