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2015 ; 43
(W1
): W258-63
Nephropedia Template TP
gab.com Text
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MyProteinNet: build up-to-date protein interaction networks for organisms,
tissues and user-defined contexts
#MMPMID25990735
Basha O
; Flom D
; Barshir R
; Smoly I
; Tirman S
; Yeger-Lotem E
Nucleic Acids Res
2015[Jul]; 43
(W1
): W258-63
PMID25990735
show ga
The identification of the molecular pathways active in specific contexts, such as
disease states or drug responses, often requires an extensive view of the
potential interactions between a subset of proteins. This view is not easily
obtained: it requires the integration of context-specific protein list or
expression data with up-to-date data of protein interactions that are typically
spread across multiple databases. The MyProteinNet web server allows users to
easily create such context-sensitive protein interaction networks. Users can
automatically gather and consolidate data from up to 11 different databases to
create a generic protein interaction network (interactome). They can score the
interactions based on reliability and filter them by user-defined contexts
including molecular expression and protein annotation. The output of MyProteinNet
includes the generic and filtered interactome files, together with a summary of
their network attributes. MyProteinNet is particularly geared toward building
human tissue interactomes, by maintaining tissue expression profiles from
multiple resources. The ability of MyProteinNet to facilitate the construction of
up-to-date, context-specific interactomes and its applicability to 11 different
organisms and to tens of human tissues, make it a powerful tool in meaningful
analysis of protein networks. MyProteinNet is available at
http://netbio.bgu.ac.il/myproteinnet.