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2015 ; 43
(W1
): W193-9
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gab.com Text
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English Wikipedia
NFFinder: an online bioinformatics tool for searching similar transcriptomics
experiments in the context of drug repositioning
#MMPMID25940629
Setoain J
; Franch M
; Martínez M
; Tabas-Madrid D
; Sorzano CO
; Bakker A
; Gonzalez-Couto E
; Elvira J
; Pascual-Montano A
Nucleic Acids Res
2015[Jul]; 43
(W1
): W193-9
PMID25940629
show ga
Drug repositioning, using known drugs for treating conditions different from
those the drug was originally designed to treat, is an important drug discovery
tool that allows for a faster and cheaper development process by using drugs that
are already approved or in an advanced trial stage for another purpose. This is
especially relevant for orphan diseases because they affect too few people to
make drug research de novo economically viable. In this paper we present
NFFinder, a bioinformatics tool for identifying potential useful drugs in the
context of orphan diseases. NFFinder uses transcriptomic data to find
relationships between drugs, diseases and a phenotype of interest, as well as
identifying experts having published on that domain. The application shows in a
dashboard a series of graphics and tables designed to help researchers formulate
repositioning hypotheses and identify potential biological relationships between
drugs and diseases. NFFinder is freely available at http://nffinder.cnb.csic.es.