Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText.
Kick-your-searchterm to multiple Engines kick-your-query now !>
A dictionary by aggregated review articles of nephrology, medicine and the life sciences
Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

suck abstract from ncbi


10.1002/glia.22702

http://scihub22266oqcxt.onion/10.1002/glia.22702
suck pdf from google scholar
C4489138!4489138 !24895267
unlimited free pdf from europmc24895267
    free
PDF from PMC    free
html from PMC    free

suck abstract from ncbi


Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24895267 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117
pmid24895267
      Glia 2014 ; 62 (10 ): 1595-607
Nephropedia Template TP

gab.com Text

Twit Text FOAVip

Twit Text #

English Wikipedia


  • The SHH/Gli pathway is reactivated in reactive glia and drives proliferation in response to neurodegeneration-induced lesions #MMPMID24895267
  • Pitter KL ; Tamagno I ; Feng X ; Ghosal K ; Amankulor N ; Holland EC ; Hambardzumyan D
  • Glia 2014[Oct]; 62 (10 ): 1595-607 PMID24895267 show ga
  • In response to neurodegeneration, the adult mammalian brain activates a cellular cascade that results in reactive astrogliosis and microgliosis. The mechanism through which astrocytes become reactive and the physiological consequences of their activation in response to neurodegeneration is complex. While the activation and proliferation of astrocytes has been shown to occur during massive neuronal cell death, the functional relationship between these two events has not been clearly elucidated. Here we show that in response to kainic acid- (KA) induced neurodegeneration, the mitogen sonic hedgehog (SHH) is upregulated in reactive astrocytes. SHH activity peaks at 7 days and is accompanied by increased Gli activity and elevated proliferation in several cell types. To determine the functional role of SHH-Gli signaling following KA lesions, we used a pharmacological approach to show that SHH secreted by astrocytes drives the activation and proliferation of astrocytes and microglia. The consequences of SHH-Gli signaling in KA-induced lesions appear to be independent of the severity of neurodegeneration.
  • |Animals [MESH]
  • |Astrocytes/drug effects/pathology/*physiology [MESH]
  • |Cell Proliferation/drug effects/*physiology [MESH]
  • |Central Nervous System Agents [MESH]
  • |Disease Models, Animal [MESH]
  • |Hedgehog Proteins/*metabolism [MESH]
  • |Hippocampus/pathology/physiopathology [MESH]
  • |Kainic Acid [MESH]
  • |Kruppel-Like Transcription Factors/genetics/*metabolism [MESH]
  • |Mice [MESH]
  • |Mice, Transgenic [MESH]
  • |Microglia/drug effects/pathology/*physiology [MESH]
  • |Neurodegenerative Diseases/pathology/*physiopathology [MESH]
  • |Neurogenesis/drug effects/physiology [MESH]
  • |Neurons/pathology/physiology [MESH]
  • |Seizures/pathology/physiopathology [MESH]
  • |Severity of Illness Index [MESH]
  • |Signal Transduction/drug effects [MESH]
  • |Veratrum Alkaloids/pharmacology [MESH]


  • DeepDyve
  • Pubget Overpricing
  • suck abstract from ncbi

    Linkout box