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10.1002/glia.22702 http://scihub22266oqcxt.onion/10.1002/glia.22702 C4489138!4489138 !24895267     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24895267 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Glia 2014 ; 62 (10 ): 1595-607 Nephropedia Template TP {{tp|p=24895267 |t=2014. The SHH/Gli pathway is reactivated in reactive glia and drives proliferation in response to neurodegeneration-induced lesions |pdf=|usr=}}{{24895267 }} gab.com Text The SHH/Gli pathway is reactivated in reactive glia and drives proliferation in response to neurodegeneration-induced lesions JO: Glia http://www.kidney.de/pget.php?&tw=1&pmid=24895267 #FOAvip In response to neurodegeneration, the adult mammalian brain activates a cellular cascade that results in reactive astrogliosis and microgliosis. The mechanism through which astrocytes become reactive and the physiological consequences of their activation in response to neurodegeneration is complex. While the activation and proliferation of astrocytes has been shown to occur during massive neuronal cell death, the functional relationship between these two events has not been clearly elucidated. Here we show that in response to kainic acid- (KA) induced neurodegeneration, the mitogen sonic hedgehog (SHH) is upregulated in reactive astrocytes. SHH activity peaks at 7 days and is accompanied by increased Gli activity and elevated proliferation in several cell types. To determine the functional role of SHH-Gli signaling following KA lesions, we used a pharmacological approach to show that SHH secreted by astrocytes drives the activation and proliferation of astrocytes and microglia. The consequences of SHH-Gli signaling in KA-induced lesions appear to be independent of the severity of neurodegeneration. Twit Text FOAVip The SHH/Gli pathway is reactivated in reactive glia and drives proliferation in response to neurodegeneration-induced lesions ????Glia http://www.kidney.de/pget.php?&tw=1&pmid=24895267 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24895267 #FOAvip English Wikipedia <ref>{{Cite pmid|24895267 }}</ref> The SHH/Gli pathway is reactivated in reactive glia and drives proliferation in response to neurodegeneration-induced lesions #MMPMID24895267 Pitter KL ; Tamagno I ; Feng X ; Ghosal K ; Amankulor N ; Holland EC ; Hambardzumyan D Glia 2014[Oct]; 62 (10 ): 1595-607 PMID24895267 show ga In response to neurodegeneration, the adult mammalian brain activates a cellular cascade that results in reactive astrogliosis and microgliosis. The mechanism through which astrocytes become reactive and the physiological consequences of their activation in response to neurodegeneration is complex. While the activation and proliferation of astrocytes has been shown to occur during massive neuronal cell death, the functional relationship between these two events has not been clearly elucidated. Here we show that in response to kainic acid- (KA) induced neurodegeneration, the mitogen sonic hedgehog (SHH) is upregulated in reactive astrocytes. SHH activity peaks at 7 days and is accompanied by increased Gli activity and elevated proliferation in several cell types. To determine the functional role of SHH-Gli signaling following KA lesions, we used a pharmacological approach to show that SHH secreted by astrocytes drives the activation and proliferation of astrocytes and microglia. The consequences of SHH-Gli signaling in KA-induced lesions appear to be independent of the severity of neurodegeneration. |Animals [MESH] |Astrocytes/drug effects/pathology/*physiology [MESH] |Cell Proliferation/drug effects/*physiology [MESH] |Central Nervous System Agents [MESH] |Disease Models, Animal [MESH] |Hedgehog Proteins/*metabolism [MESH] |Hippocampus/pathology/physiopathology [MESH] |Kainic Acid [MESH] |Kruppel-Like Transcription Factors/genetics/*metabolism [MESH] |Mice [MESH] |Mice, Transgenic [MESH] |Microglia/drug effects/pathology/*physiology [MESH] |Neurodegenerative Diseases/pathology/*physiopathology [MESH] |Neurogenesis/drug effects/physiology [MESH] |Neurons/pathology/physiology [MESH] |Seizures/pathology/physiopathology [MESH] |Severity of Illness Index [MESH] |Signal Transduction/drug effects [MESH] |Veratrum Alkaloids/pharmacology [MESH]The SHH/Gli pathway is reactivated in reactive glia and drives prolife(epmc).pdf DeepDyve Pubget Overpricing