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2015 ; 5
(ä): 11323
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
The sexually driven epidemic in youths in China s southwestern border region was
caused by dynamic emerging multiple recombinant HIV-1 strains
#MMPMID26133091
Wei H
; Xing H
; Hsi JH
; Jia M
; Feng Y
; Duan S
; He C
; Yao S
; Ruan Y
; He X
; Liao L
; Ma Y
; Huang Y
; Lu L
; Shao Y
Sci Rep
2015[Jul]; 5
(ä): 11323
PMID26133091
show ga
Dehong prefecture, Yunnan province on China's southwestern border was the gateway
of the country's AIDS epidemic. Studies on HIV-1 molecular epidemiology will
provide key information on virus transmission dynamics and help to inform HIV
prevention strategies. HIV-1 infected youths (age 16-25 years) diagnosed in the
continuous 3 months in 2009 to 2012 were enrolled. By means of phylogenetic and
statistical analyses, It was showed that two thirds (133/205) of youths in
Dehong, of which 74.1% were infected sexually, were infected by uncharacterized
recombinant HIV-1 strains. Among them about 59.4% (79/131) were unique
recombinant forms (URFs) and 40.6% (54/131) formed 11 transmission clusters,
termed potential circulating recombinant forms (pCRFs). The emergence of
recombinants was statistically significant related with people of low education,
residents outside the capital city of Dehong and being Myanmar residents. It was
the first report with ongoing HIV-1 recombinant strains in a sexually driven
epidemic area in China. Great efforts should be put on reducing multiple risk
exposures behavior in local young people, containing the spread of pCRFs to other
regions, and preventing the URFs from evolving into future CRFs. Collaborative
prevention across border is needed to better control the local AIDS epidemic.