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Folate and nutrients involved in the 1-carbon cycle in the pretreatment of
patients for colorectal cancer
#MMPMID26043032
Ferrari A
; de Carvalho AM
; Steluti J
; Teixeira J
; Marchioni DM
; Aguiar S Jr
Nutrients
2015[Jun]; 7
(6
): 4318-35
PMID26043032
show ga
To assess the ingestion of folate and nutrients involved in the 1-carbon cycle in
non-treated patients with colorectal adenocarcinoma in a reference center for
oncology in southeastern Brazil. In total, 195 new cases with colorectal
adenocarcinoma completed a clinical evaluation questionnaire and a Food Frequency
Questionnaire (FFQ). Blood samples from 161 patients were drawn for the
assessment of serum folate. A moderate correlation was found between serum
concentrations of folate, folate intake and the dietary folate equivalent (DFE)
of synthetic supplements. Mulatto or black male patients with a primary
educational level had a higher intake of dietary folate. Of patients obtaining
folate from the diet alone or from dietary supplements, 11.00% and 0.10%,
respectively, had intake below the recommended level. Of the patients using
dietary supplements, 35% to 50% showed high levels of folic acid intake. There
was a prevalence of inadequacy for vitamins B2, B6 and B12, ranging from 12.10%
to 20.18%, while 13.76% to 22.55% of patients were likely to have adequate
choline intake. The considerable percentage of patients with folate intake above
the recommended levels deserves attention because of the harmful effects that
this nutrient may have in the presence of established neoplastic lesions.
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